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Ceftazidime with avibactam for treating severe aerobic Gram-negative bacterial infections: technology evaluation to inform a novel subscription-style payment model.

Health Technol Assess
Harnan S, Kearns B, Scope A, Schmitt L, Jankovic D, Hamilton J, Srivastava T, Hill H, Ku CC, Ren S, Rothery C, Bojke L, Sculpher M, Woods B.   +13 more
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Combating multidrug-resistant Gram-negative bacterial infections

Expert Opinion on Investigational Drugs, 2013
Multidrug-resistant (MDR) bacterial infections, especially those caused by Gram-negative pathogens, have emerged as one of the world's greatest health threats. The development of novel antibiotics to treat MDR Gram-negative bacteria has, however, stagnated over the last half century.This review provides an overview of recent R&D activities in the ...
Ze-Qi, Xu, Michael T, Flavin, John, Flavin   +2 more
openaire   +2 more sources

Endotoxinʼs role in Gram-negative bacterial infection

Current Opinion in Infectious Diseases, 1995
Gram-negative bacterial endotoxin has diverse and profound effects on immunocompetent cells, both in vitro and in vivo. During this past year considerable attention was directed towards defining the mechanisms by which cells recognize endotoxin and in examining the fine structure of the proteins involved. Because of the importance of lipopolysaccharide
Alan S. Cross, Steven M. Opal
openaire   +1 more source

Multidrug-resistant Gram-negative bacterial infections

The Lancet
Multidrug-resistant Gram-negative bacterial infections cause significant morbidity and mortality globally. These pathogens easily acquire antimicrobial resistance (AMR), further highlighting their clinical significance. Third-generation cephalosporin-resistant and carbapenem-resistant Enterobacterales (eg, Escherichia coli and Klebsiella spp ...
Nenad, Macesic, Anne-Catrin, Uhlemann, Anton Y, Peleg   +2 more
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Gram‐negative bacterial toe web infection – a systematic review

Journal of the European Academy of Dermatology and Venereology, 2017
AbstractGram‐negative bacterial toe web infection (GNBTWI) is a frequent therapeutic challenge in clinical practice with high recurrence rates and frequent need of systemic drugs. The aim of this systematic review was to provide an updated overview and evidence‐based data on pathogens, risk factors and treatment of GNBTWI along with promoting a ...
T, Weidner, J, Tittelbach, T, Illing, P, Elsner   +3 more
openaire   +2 more sources

Inhibiting Heptosyltransferase to Combat Gram‐Negative Bacterial Infections

The FASEB Journal, 2020
Lipopolysaccharides (LPS) embedded in the outer membrane of Gram‐negative bacteria are known to enable antibiotic resistance by providing protection from hydrophobic antibiotics and assisting biofilm development. One of the key enzymes for synthesizing LPS is heptosyltransferase I (HepI),
Alvin Wang, Colleen Castro, Erika Taylor
openaire   +1 more source