Results 201 to 210 of about 6,569,074 (300)

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

Systematic characterization of PBP2 as the primary siderophore recognizer in <i>Actinomycetes</i> and other Gram-positive bacteria. [PDF]

Microb Genom
Yu L, Xiong G, Li Z.
europepmc   +1 more source

Phenotypic resistance to life-saving antimicrobials in Gram-positive bacteria isolated from wild birds in Northern Italy: a One Health surveillance perspective. [PDF]

One Health
Rapi MC, Filipe J, Penati M, Pavesi LF, Addis MF, Raimondi S, Grilli G.   +6 more
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Domestic pig skin peptides: targeted starvation therapy for gram-positive bacteria MRSA through ABC transporters. [PDF]

BMC Microbiol
Zhang Q, Huang S, Che K, Yin Z, Wang X, Zhang L, Lin Y, Cai D, Zhang J.   +8 more
europepmc   +1 more source

Synergistic antibacterial effect of CATH-2 and D-amino acids against mastitis causing gram-positive bacteria. [PDF]

Front Cell Infect Microbiol
Veldhuizen EJA, van der Velden ST, Alons D, Benedictus L, van der Drift I, Ludwig IS, Schreutelkamp DE, Wösten MMSM.   +7 more
europepmc   +1 more source

Structure-Activity Relationships of Cannabigerol and Cannabigerolic Acid Derivatives as Antibacterial Agents against Gram-Positive Bacteria. [PDF]

ACS Omega
Mandal PS, Coleman LM, Kumar V, Walker DE, Thompson JC, Singh S.   +5 more
europepmc   +1 more source

Antibacterial and antibiofilm activity of a triterpenoid-rich Eucalyptus globulus leaf extract against gram-positive bacteria. [PDF]

Sci Rep
Spaggiari C, Spadini C, Righetti L, Mezzasalma N, Cupola A, Pieroni M, Annunziato G, Cabassi CS, Costantino G.   +8 more
europepmc   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram-Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach. [PDF]

Adv Sci (Weinh)
Chen K, Liang J, Wu Y, Xu J, Liu Y, Wang W, Jiang X, Gao B, Wang Y, Jiang H.   +9 more
europepmc   +1 more source