Results 161 to 170 of about 9,152,759 (299)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Editorial: Research ethics and integrity in the artificial intelligence era. [PDF]

Front Res Metr Anal
Chigwada J, Ngulube P.
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Human-Constrained AI-Assisted Identification of Defect-Topology Relations for Mechanical Degradation in Porous Solids: A Discrete-Element Study. [PDF]

Materials (Basel)
Zhang Y, Liu Y, Xie H.
europepmc   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Case Studies in Fluid Construction Grammar The Verb Phase

This book shows that construction grammar gives us also a powerful new way to conceive and implement operational parsing and production systems, which could be used as a basic component of a wide range of Artificial Intelligence applications, such as ...
Beuls, Katrien., Steels, Luc.
core  

Significant Relationships between EFL Teachers’ Practice and Knowledge in the Teaching of Grammar in Libyan Secondary Schools [PDF]

Studies of teacher cognition and the teaching of grammar have attracted increasing research attention in recent years, yet relatively little has been published about how EFL teachers working in secondary schools teach grammar compared to what they know ...
Tantani, Abdussalam Saleh Nasser
core  

Geranium: Multimodal Retrieval of Genomics Data Visualizations. [PDF]

IEEE Trans Vis Comput Graph
Nguyen HN, L'Yi S, Smits TC, Gao S, Zitnik M, Gehlenborg N.   +5 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Essentials of Cognitive Grammar

Tailored to students, this abridged version of Cognitive Grammar positions Langacker's authoritative work as an accessible, attractive cornerstone of cognitive linguistics as the field continues to evolve.Cover -- Contents -- Part I: Meaning and ...
Langacker, Ronald W.
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