Results 41 to 50 of about 1,267,937 (277)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Lexemic and syntactic influence on aspect (example of Slovenian)
Opera slavica, 2013 The article discusses aspect as a morphological, lexical and syntactic phenomenon, which in turn testifies to its specific nature tied to the particularity of each individual system of language. In the article we discuss aspect in Slovenian.
Andreja Žele
doaj
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Görünüş Terimlerinin Türkçeleştirilmesi Üzerine Bazı Gözlem ve Öneriler
Dilbilim Araştırmaları Dergisi, 2008 This study focuses on a number of grammatical and lexical aspect terms and their Turkish counterparts. Key terms are briefl y defi ned and the choice of various terms is justifi ed. In addition, some Turkish translations are suggested for those aspectual
Mine Güven
doaj
The communicative contexts of grammatical aspect use in English [PDF]
Journal of Child Language, 2013 ABSTRACTIn many of the world's languages grammatical aspect is used to indicate how events unfold over time. In English, activities that are ongoing can be distinguished from those that are completed using the morphological marker -ing. Using naturalistic observations of two children in their third year of life, we quantify the availability and ...
Ibbotson, Paul +2 more
openaire +5 more sources
Arthritis Care &Research, EarlyView.Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule +4 more
wiley +1 more source
Grammatical verb aspect and event roles in sentence processing. [PDF]
PLoS ONE, 2017 Two experiments examine how grammatical verb aspect constrains our understanding of events. According to linguistic theory, an event described in the perfect aspect (John had opened the bottle) should evoke a mental representation of a finished event ...
Carol Madden-Lombardi +2 more
doaj +1 more source