Results 181 to 190 of about 4,451 (294)
Journal of the Royal Anthropological Institute, EarlyView.What does it take to turn a tool into a talking tool and that into an ultimate authority? Generative artificial intelligence (GenAI) in its diverse forms, such as large language models (LLMs), is celebrated as a useful tool. But LLM‐based conversational agents, or chatbots, the software applications through which ordinary users are likely to engage ...
Webb Keane
wiley +1 more source
Chemical and Region Equilibria with Heterogeneous Fluids Using Classical Density Functional Theory. [PDF]
J Phys Chem BPereira IPS +4 more
europepmc +1 more source
British Journal of Psychotherapy, EarlyView.Abstract This article examines how change becomes possible in couple discourse within psychoanalytic couple therapy. It proposes “couple discourse” as a clinical and theoretical concept for listening to the ways partners signify, project and transform experience together.
Keren Cohen
wiley +1 more source
Out of the Crystalline Comfort Zone: Sampling the Initial Oxide Formation At Cu(111). [PDF]
Adv Sci (Weinh)Riccius F +3 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Learning with a Warmer World: Climate Change Education for Forms of Life*
Educational Theory, EarlyView.Abstract Climate change poses a threat to young people's capacity to flourish both now and in the future. In response, Aristotelian Climate Change Education (CCE) aims to cultivate radicalized climate virtues in students and give them structured opportunities to contemplate Socrates's question—“How should one live?”—amidst conditions of unprecedented ...
Melissa Diamond, Tomas Rocha
wiley +1 more source
The Grand Canonical General-Purpose Reactivity Indicator: A Conceptual DFT Approach to Predict Molecular Reactivity and Experimental Electrophilicity and Nucleophilicity Scales. [PDF]
J Chem Theory ComputBarrera Y +4 more
europepmc +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Thermodynamically Consistent Enthalpies of Adsorption of Mixtures from Classical Density Functional Theory. [PDF]
J Phys Chem BRehner P.
europepmc +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source