Results 241 to 250 of about 4,905,659 (296)

A prospective external validation of the GRade, Age, Nodes and Tumor score in the ECOG-ACRIN EA8143 PROSPER trial. [PDF]

Oncologist
Buti S, Kim SE, Maffezzoli M, Allaf ME, Giudice GC, Banna GL, Taguchi S, Haas NB, Carducci MA.   +8 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Composable free-space continuous-variable quantum key distribution using discrete modulation. [PDF]

Sci Adv
Jaksch K, Dirmeier T, Weiser Y, Richter S, Bayraktar Ö, Hacker B, Rößler C, Khan I, Petscharning S, Grafenauer T, Hentschel M, Ömer B, Pacher C, Kanitschar F, Upadhyaya T, Lin J, Lütkenhaus N, Leuchs G, Marquardt C.   +18 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Ab initio determination of phase stabilities of dynamically disordered solids: rotational C₂ disorder in Li₂C₂. [PDF]

Sci Rep
Klarbring J, Filippov S, Häussermann U, Simak SI.   +3 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Martini 3 Metabolome. [PDF]

J Chem Theory Comput
Brasnett C, Brown CM, Grünewald L, Stevens JA, Marrink SJ.   +4 more
europepmc   +1 more source

Experimental violation of a Bell-like inequality for causal order. [PDF]

Sci Adv
Guo Y, Tang H, Wang BX, Lv MY, Fan JW, Hu XM, Huang YF, Li CF, Guo GC, Chiribella G, Liu BH.   +10 more
europepmc   +1 more source

Diff-MomentFormer: Generative Diffusion-Augmented Transformer for End-to-End Joint Moment Estimation. [PDF]

Sensors (Basel)
Qiao C, Liu E, Ren J, He L.
europepmc   +1 more source