Results 261 to 270 of about 4,217,946 (332)

Switching from anti-CD20 therapies to cladribine and vice versa - Analysis of a German relapsing multiple sclerosis cohort. [PDF]

Neurotherapeutics
Konen FF, Pfeuffer S, Jendretzky KF, Gehring K, Elias-Hamp B, Sühs KW, Halle S, Brand K, Lichtinghagen R, Willemse E, Pawlitzki M, Kuhle J, Meuth SG, Kleinschnitz C, Pul R, Skripuletz T.   +15 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pentafluoroethyl Sulfoximine Reagent for the Photocatalytic Pentafluoroethylation-Difunctionalization of Styrene Derivatives. [PDF]

Org Lett
Lin L, Goujon G, Pégot B, Dagousset G, Anselmi E, Magnier E, Tsui GC.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals. [PDF]

Alzheimers Dement Behav Socioecon Aging
Windon CC, Tsoy E, Livaudais-Toman J, Neilands TB, Palmer NR, Heston MB, Johnson JK, Hanna L, Gatsonis C, Romanoff J, Steingrimsson J, Carrillo MC, Dilworth-Anderson P, Hillner BE, Siegel BA, Whitmer RA, Wilkins CH, Smith K, Blazhenets G, La Joie R, Miller BL, Possin KL, Rabinovici GD.   +22 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Fiscal federalism, inter-governmental transfers and public health- The case of Urban Local Bodies in India.

SSM Health Syst
Chowdhury S.
europepmc   +1 more source

Medical Cannabis and Opioid Receipt Among Adults With Chronic Pain. [PDF]

JAMA Intern Med
Slawek DE, Zhang C, Dahmer S, Sohler N, Zolotov Y, Starrels JL, Deng Y, Calderon DiFrancesca G, Levin FR, Ross J, Minami H, Cunningham CO, Arnsten JH.   +12 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source