Results 71 to 80 of about 4,217,946 (332)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FOREIGN AID TO UKRAINE AFTER 2014: VOLUMES, PROJECTS AND DONORS’ MOTIVATION
Vestnik MGIMO-Universiteta, 2018 The article deals with assistance aid provided by the international donors to Ukraine. Author analyzes Ukrainian statistics on the issue – the projects registered between January 2014 and February 2018 by two Ukrainian ministries – the Ministry of ...
O. V. Shishkina
doaj +1 more source
Intergovernmental Grants as Signals and the Alignment Effect: Theory and Evidence
Social Science Research Network, 2015 This paper provides a simple political agency model to explain the effect of political alignment between different tiers of government on intergovernmental grants and election outcomes.
Emanuele Bracco +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Reflections on Evaluating our Grants [PDF]
, 2004 Presents observations and experiences from TCWF's first twelve years of grantmaking. Includes specific case studies and shares some lessons learned as it applies to the field of evaluation for philanthropy.
Ruth Tebbets Brousseau
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
New York State Competitive Grants: Creating a System of Education Winners and Losers [PDF]
, 2012 This study highlights the significant downside of the introduction of competitive grants into the New York school finance system. It makes a strong case that these grants have actually been substituted for aid programs, such as the Foundation Formula ...
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Identifying Elements for a Successful Approach to Applying Projects [PDF]
International Journal of Management, Knowledge and Learning, 2018 This paper presents elements for a successful approach to addressing Horizon 2020. Horizon 2020 is the EU programme offering funding for research and innovation projects.
Urska Vidmar, Tina Vukasovic
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source