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Granulation techniques and technologies: recent progresses
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules.
S. Shanmugam
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Granulation time in fluidized bed granulators [PDF]
Size enlargement of particles in fluidized bed granulation involves mixing of particles with a binder liquid to form larger wet granules and drying them to form dry granules. Identification of the time for completion of granulation process is critical as further fluidization of dry granules is providing extra energy for their attrition.
Papiya Roy+2 more
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Alternative Granulation Technique: Melt Granulation
Drug Development and Industrial Pharmacy, 1996AbstractA melt granulation process has been investigated (1, 2) which efficiently agglomerates pharmaceutical powders for use in both immediate- and sustained-release solid dosage forms. The process utilizes materials that are effective as granulating fluids when they are in the molten state.
Alan Royce+3 more
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Effect of the Granulation Process on Nitrofurantoin Granule Characteristics
Drug Development and Industrial Pharmacy, 1998We studied four granulation methods on the same quantitative and qualitative formula: wet massing by forced agglomeration (Lödige) and free agglomeration (Glatt); and dry massing by slugging and roller compaction technique. Three different particle sizes of nitrofurantoin (bioinequivalent drug) were used. The nitrofurantoin particle size has a very low
Ph. Arnaud+2 more
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Effects of High-Shear Granulation on Granulate Homogeneity
Pharmaceutical Development and Technology, 1999This study considers the effects of particle size of the powder constituents, and of impeller speed on the homogeneity of drug distribution on granulations produced in high-speed mixers. When a micronized low-dose steroid hormone was granulated together with unmicronized lactose in a Vactron 75 high-shear granulator at 250 rpm, strong inhomogeneities ...
Harriette G. M. Poels-Janssen+2 more
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Intelligent granules: Are eosinophil crystalloid granules inimitable?
Journal of Allergy and Clinical Immunology, 2010The controversy surrounding the effector function of eosinophils in health and disease continues at both the clinical and basic discovery levels. Two recent studies reported that an anti-human IL-5 mAb (mepolizumab) specifically targeting eosinophils significantly reduced asthma exacerbations, providing interesting insights into the potential role of ...
Redwan Moqbel+2 more
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Granulation of Acetaminophen by a Rotating Fluidized-Bed Granulator
Pharmaceutical Development and Technology, 2000The purpose of this research was to evaluate the use of a rotating fluidized-bed granulator to produce acetaminophen granules with sufficient binding force between particles and good plasticity in tablets. Ethenzamide and ascorbic acid were used to compare the relationship between granulation and the sample wetness.
Kanji Fujita+9 more
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Microbial communities of aerobic granules: Granulation mechanisms
Bioresource Technology, 2014Aerobic granulation is an advanced biological wastewater treatment technology. This study for the first time identified the microbial communities of sliced samples of mature granules by polymerase chain reaction (PCR) amplification and denaturing gradient gel electrophoresis (DGGE) technique and those of whole growing granules by high-throughput ...
Duu-Jong Lee+6 more
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STABILITY OF INFORMATION GRANULATION AND INFORMATION GRANULES
International Journal of Computational Intelligence and Applications, 2002In this study, we introduce a notion of stability of information granules. Granulation of information results in a series of chunks of information usually referred to as information granules. Information granules are basic building entities involved in the formation of a broad class of systems.
George Vukovich+2 more
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A study on the preparation of granules by mixer granulation
Archives of Pharmacal Research, 1979A first systematic approach on new and simple preparation method of spherical granules in the system using organic granulating solution was carried out. Mixer granulation required narrow range of moisture content but gentle action of tumbling in the mixer and capillary forces were adequate to compact the porous mass and also were highly effective to ...
Shanghi Rhee+3 more
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