Granulocyte-colony stimulating factor

Southern Medical Journal, 1993
Recombinant human granulocyte colony-stimulating factor (G-CSF) is a nonglycosylated protein produced in Escherichia coli using recombinant DNA technology. G-CSF was first defined in vitro as a relatively selective stimulator of pure granulocyte colonies from normal marrow and as a factor that induces differentiation of leukemic cell lines.
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Granulocyte Colony-Stimulating Factors

2004
Granulocyte colony-stimulating factor (G-CSF) is a major regulator of the development of antibacterial neutrophilic granulocytic leukocytes (neutrophils). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-
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Granulocyte Colony-Stimulating Factor

1990
Neutrophils have a very limited life span and must be replaced constantly by proliferation and differentiation of precursor cells in the bone marrow which become mature blood cells. From studies on the proliferation and differentiation of hematopoietic progenitor cells in vitro in semisolid culture systems (Metcalf 1984) it has become evident that ...
K. Welte, E. Platzer
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Granulocyte colony stimulating factor.

Methods in enzymology, 1986
Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be ...
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granulocyte colony-stimulating factor
humans
granulocyte colony‐stimulating factor

diseases of the blood and blood-forming organs
neutropenia
animals

3. good health
hematopoietic stem cells
hematopoiesis