Results 61 to 70 of about 121,033 (200)

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells

, 2004
The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Jakupovic, I., Khwaja, A., Grandage, V.L., Linch, D.C.   +3 more
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Granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor infusion makes high-dose etoposide a safe outpatient regimen that is effective in lymphoma and myeloma patients

, 1992
This study assessed the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) or recombinant human granulocyte colony-stimulating factor (rhG-CSF) in ameliorating the extent and duration of hematologic toxicity after ...
S. Siena, M. Bregni, G. Bonadonna, A. M. Gianni, A. Pileri, F Lombardi, M. Di Nicola, Tarella, Corrado, A M Gianni, F. Lombardi, M. Magni, C Tarella, S Siena, G Bonadonna, M Bregni, A Pileri, Pileri, Alessandro, M Di Nicola, C. Tarella, M Magni   +19 more
core   +1 more source

Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092) [PDF]

, 2006
Background and Purpose - Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell types, including neurones, glia, and vascular cells.
Dennis, Martin S., Willmot, Mark, Walker, Marion F., Sprigg, Nikola, Zhao, Lian, Russell, Nigel, Bath, Philip M.W., Gray, Laura J.   +7 more
core   +1 more source

Bone marrow dysfunction in diabetes [PDF]

, 2013
Background. Diabetes mellitus (DM) increases cardiovascular disease (CVD) and this is attributed, at least in part, to shortage of vascular regenerative cells derived from the bone marrow (BM).
Fadini, Gian Paolo
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CSF-1 as a regulator of macrophage activation and immune responses

, 2003
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g.
Sweet, MJ, Sweet, Matthew J, Hume, David A, Hume, DA   +3 more
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Clinical manifestations and outcomes of pediatric chronic neutropenia

Journal of the Formosan Medical Association, 2012
Neutropenia is a decrease in the number of circulating neutrophils. When neutropenia persists for more than 3 months, it becomes chronic. A heterogeneous group of diseases in children can cause chronic neutropenia.
Chuan Wan, Hsin-Hui Yu, Meng-Yao Lu, Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Yao-Hsu Yang, Bor-Luen Chiang   +7 more
doaj   +1 more source

Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor [PDF]

, 2017
PURPOSE/BACKGROUND: Clozapine is associated with hematological abnormalities, notably neutropenia, which may progress to agranulocytosis. Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have ...
Eromona Whiskey, Amir Krivoy, Flanagan, Robert J., Lally, John, John Lally, David M. Taylor (4342150), Robert J. Flanagan, James H. MacCabe (7955552), Fiona P. Gaughran (7955543), MacCabe, James H.; id_orcid, Aleksandar Mijovic (7955549), Aleksandar Mijovic, Mijovic, Aleksandar, David M. Taylor, Eromona Whiskey (7955540), Malik, Steffi, Gaughran, Fiona P.; id_orcid, John Lally (7896821), James H. MacCabe, Taylor, David M.; id_orcid, Steffi Malik (7955525), Whiskey, Eromona, Amir Krivoy (6667283), Steffi Malik, Robert J. Flanagan (7955546), Krivoy, Amir, Fiona P. Gaughran   +26 more
core   +1 more source

Modeling the Hematopoietic Landscape

Frontiers in Cell and Developmental Biology, 2019
Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then “merely” differentiate.
Geoffrey Brown, Rhodri Ceredig
doaj   +1 more source

Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages

, 2000
Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived ...
H Chan (7732445), S Sonza (13719724), A Maerz (13711384), S Crowe (13428231), T Warby (13726843), K Kedzierska (9863357), A Lopez (7734548), A Jaworowski (9684227), Johnson Mak (13082904)   +8 more
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Phase 1 study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers

, 2004
We assessed the safety, tolerability and efficacy of the immunomodulatory drug, CC-5013 (REVIMID(TM)), in the treatment of patients with metastatic malignant melanoma and other advanced cancers.
Muller, G.W., Dredge, K., Clarke, IA, Kristeleit, H., Dredge, K, D I Stirling, A G Dalgleish, Zeldis, J., S Nicholson, Polychronis, A., Kristeleit, H, G W Muller, H Kristeleit, J B Bartlett, Nicholson, S, K Dredge, Stirling, D.I., Michael, A, Dalgleish, A.G., Polychronis, A, Muller, GW, Pandha, H,, Stirling, DI, I A Clarke, Clarke, I.A., Bartlett, JB, Zeldis, J, Nicholson, S., H Pandha, Dalgleish, AG, J Zeldis, Pandha, H, A Polychronis, Michael, A., A Michael, Bartlett, J.B.   +35 more
core   +1 more source