Results 221 to 230 of about 30,079 (265)

Epidemiology of granulomatosis with polyangiitis and microscopic polyangiitis in adults in France

Journal of Autoimmunity, 2022
BACKGROUND Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare systemic necrotizing vasculitis. The national incidence and prevalence of GPA/MPA and patient mortality remain unknown in France.
Pierre Bataille, Benjamin Terrier
exaly   +2 more sources

Efficacy and Safety of Reslizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis (EGPA).

Annals of Allergy, Asthma & Immunology, 2021
BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA), a rare vasculitis with significant morbidity, is characterized by asthma, eosinophilia, sinusitis, pulmonary infiltrates, neuropathy, +ANCA, and multi-organ vasculitis.
L. Manka, V. Guntur, J. Denson, Ryan M. Dunn, Yeshai Dollin, M. Strand, M. Wechsler   +6 more
semanticscholar   +1 more source

Sequential rituximab and mepolizumab in eosinophilic granulomatosis with polyangiitis (EGPA): a European multicentre observational study

Annals of the Rheumatic Diseases, 2022
Eosinophilic granulomatosis with polyangiitis (EGPA) is an antineutrophil cytoplasmic antibody (ANCA)associated vasculitis characterised by eosinophilic (eg, respiratory involvement, cardiomyopathy, gastroenteritis) and vasculitic manifestations (eg ...
A. Bettiol, M. Urban, F. Bello, D. Fiori, I. Mattioli, G. Lopalco, F. Iannone, A. Egan, L. Dagna, M. Caminati, S. Negrini, Elena Bargagli, M. Folci, F. Franceschini, R. Padoan, O. Flossmann, R. Solans, J. Schroeder, M. André, L. Moi, P. Parronchi, D. Roccatello, S. Sciascia, D. Jayne, D. Prisco, A. Vaglio, G. Emmi   +26 more
semanticscholar   +1 more source

Therapeutic advances in eosinophilic granulomatosis with polyangiitis

Current Opinion in Rheumatology, 2022
Purpose of review In recent years, therapeutic advances in eosinophilic granulomatosis with polyangiitis (EGPA) have changed our treatment paradigm. This review will summarize and discuss updates in management of EGPA, with a particular focus on biologic
Julia A. Ford, Y. Aleatany, Ora Gewurz-Singer   +2 more
semanticscholar   +1 more source

Granulomatosis with Polyangiitis in Childhood

Current Rheumatology Reports, 2012
Granulomatosis with polyangiitis (GPA) is a rare yet frequently organ- or life-threatening systemic vasculitis affecting small- to medium-sized arteries in multiple organs. It characteristically leads to alveolar hemorrhage and destructive, pauci-immune glomerulonephritis. GPA is also characterized by granulomas in the upper and lower respiratory tract
Marinka, Twilt, Susanne, Benseler, David, Cabral   +2 more
openaire   +2 more sources

Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis.

New England Journal of Medicine
BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by eosinophilic inflammation. Benralizumab, a monoclonal antibody against the interleukin-5α receptor expressed on eosinophils, may be an option for treating ...
Michael E. Wechsler, P. Nair, B. Terrier, Bastian Walz, A. Bourdin, D. Jayne, D. J. Jackson, F. Roufosse, L. Börjesson Sjö, Ying Fan, M. Jison, C. Mccrae, S. Necander, A. Shavit, C. Walton, Peter A. Merkel   +15 more
semanticscholar   +1 more source

Long-term Effectiveness of Benralizumab in Eosinophilic Granulomatosis with Polyangiitis.

Journal of Allergy and Clinical Immunology: In Practice
BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a multi-systemic disease characterised by eosinophilic tissue inflammation. Benralizumab, an anti-IL-5-receptor monoclonal antibody, induces rapid depletion of eosinophils; its longer ...
A. Nanzer, Anne-Catherine Maynard-Paquette, V. Alam, L. Green, L. Thomson, J. Lam, M. Fernandes, C. Roxas, G. D'ancona, A. Hearn, Jessica Gates, Sangita Agarwal, Brian D. Kent, Michelle Fernando, David D’Cruz, Claire Hopkins, Tevfik F. Ismail, J. Dhariwal, David J. Jackson   +18 more
semanticscholar   +1 more source

Biologics for eosinophilic granulomatosis with polyangiitis

Current Opinion in Allergy and Clinical Immunology, 2022
Purpose of review The link between severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA) in terms of pathophysiological background, clinical manifestations and disease evolution has leaded to investigate the relevance of anti T2 ...
M. Caminati, M. Maule, F. Bello, G. Emmi
semanticscholar   +1 more source

Granulomatosis with polyangiitis (Wegener's)

Joint Bone Spine, 2020
Granulomatosis with polyangiitis (GPA) (Wegener) is a necrotizing vasculitis combining inflammation of the vascular wall and peri- and extravascular granulomatosis. Clinically, GPA is characterized in its full form by ENT signs, lung, and kidney involvement.
openaire   +2 more sources

Eosinophilic granulomatosis with polyangiitis: understanding the disease and its management.

Rheumatology, 2020
Eosinophilic granulomatosis with polyangiitis is characterized by asthma, blood and tissue eosinophilia and small-vessel vasculitis. The clinical presentation is variable, but two main clinic-pathologic subsets can be distinguished: one hallmarked by ...
Giorgio Trivioli, B. Terrier, A. Vaglio
semanticscholar   +1 more source