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A proposed cascade of vascular events leading to granulomatous amoebic encephalitis
Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the ...
Naveed Ahmed Khan, Abdul Mannan Baig
exaly +4 more sources
Acanthamoeba spp. is a ubiquitous free-living amoeba that causes human infections affecting predominantly the cornea and central nervous system. The diagnosis and treatment of Acanthamoeba encephalitis is very challenging.A 53-year-old male with HIV/AIDS was admitted for altered mental status and fever.
Hsien Lee Lau +11 more
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Clinical Rheumatology, 1998
A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused by Acanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection.
Tsutomu Takeuchi, J Koide, S Itoyama
exaly +3 more sources
A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused by Acanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection.
Tsutomu Takeuchi, J Koide, S Itoyama
exaly +3 more sources
Imaging monitoring of Balamuthia granulomatous amoebic encephalitis
Clinical Neurology and NeurosurgeryBalamuthia granulomatous amoebic encephalitis (GAE) is a rare and highly lethal infectious disease affecting the central nervous system, caused by the Balamuthia amoeba. This article reports the case of a child with normal immune function and no apparent epidemiological risk factors.
Jinzhi, Mei +3 more
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Granulomatous amoebic encephalitis (GAE) is caused by two protist pathogens, Acanthamoeba spp., and Balamuthia mandrillaris. Although rare, it almost always results in death. In the present study, amoebae were treated with various combinations of clinically-approved drugs, targeting vital cellular receptors and biochemical pathways.
Kulsoom, Huma +3 more
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Motile trophozoites in granulomatous amoebic encephalitis
QJM - Monthly Journal of the Association of PhysiciansVinay Khanna +2 more
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Granulomatous amoebic encephalitis due to leptomyxid amoebae: report of the first Brazilian case.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1992Leila Chimelli +2 more
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