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Granulomatous amoebic encephalitis (GAE) is caused by two protist pathogens, Acanthamoeba spp., and Balamuthia mandrillaris. Although rare, it almost always results in death. In the present study, amoebae were treated with various combinations of clinically-approved drugs, targeting vital cellular receptors and biochemical pathways.
Abdul Mannan Baig +2 more
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A Case of Granulomatous Amoebic Encephalitis diagnosed and intervened at an Early Stage
Tomoya Ogawa +2 more
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Successful Treatment of Granulomatous Amoebic Encephalitis with Combination Antimicrobial Therapy
Granulomatous amoebic encephalitis (GAE) is a rare but fatal infection. Due to its nonspecific symptoms and laboratory and neuroradiological findings, it is rarely diagnosed antemortem. We herein present the case of a 72-year-old Japanese woman who was diagnosed with GAE following the detection of a pathogen similar to Balamuthia mandrillaris under a ...
Hiroyuki Yuasa, Tatsuru Hara
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Granulomatous amoebic encephalitis presenting as a solitary mass lesion
Abstract Granulomatous amoebic encephalitis is a rare progressive infectious disease of the central nervous system with a high mortality rate. It usually presents as multiple ring-enhancing lesions in the brain with surrounding edema evident, while the granulomatous amoeba encephalitis reported in this case is manifested as a solitary mass in the ...
Nian Xia Fu
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Granulomatous Amoebic Encephalitis Caused by Balamuthia Mandrillaris in an Immunocompetent Girl
World Neurosurgery, 2012Balamuthia mandrillaris is a recently recognized cause of a rare, devastating infection, granulomatous amoebic encephalitis (GAE). Presenting symptoms of GAE are nonspecific and can last for months before becoming clinically significant. Once the infection involves the central nervous system, death often results within days to weeks.
Martin E Weinand
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Granulomatous Amoebic Encephalitis Caused by Balamuthia Mandrillaris -Case Report-
Hisao Uehara +2 more
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Clinical Rheumatology, 1998
A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused by Acanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection.
J Koide, Tsutomu Takeuchi, Mori S
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A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused by Acanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection.
J Koide, Tsutomu Takeuchi, Mori S
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Imaging monitoring of Balamuthia granulomatous amoebic encephalitis
Clinical Neurology and NeurosurgeryBalamuthia granulomatous amoebic encephalitis (GAE) is a rare and highly lethal infectious disease affecting the central nervous system, caused by the Balamuthia amoeba. This article reports the case of a child with normal immune function and no apparent epidemiological risk factors.
Chenmei Zhang
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Balamuthia mandrillaris Granulomatous Amoebic Encephalitis: The First African Experience
Journal of the Pediatric Infectious Diseases Society, 2022Abstract We report the first case of Balamuthia mandrillaris granulomatous amoebic encephalitis definitively acquired in Africa. Our case emphasizes initial nonspecific dermatological features, delays in confirmation of the diagnosis, difficulties accessing recommended medication, and uncertainty about optimal treatment of a disease with
Hafsah D Tootla +9 more
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Fatal granulomatous amoebic encephalitis caused by Balamuthia mandrillaris
Medical Journal of Australia, 1997Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris is rare (63 human) cases reported worldwide) and fatal. We report a case in a five-year-old boy who had previously been well. For 18 months, he had had a slowly progressive, granulomatous mid facial lesion, but despite extensive investigation definitive diagnosis was made only with ...
Reed, R.P. +6 more
openaire +4 more sources

