Results 51 to 60 of about 913,894 (219)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Graph Entropy Associated with Multilevel Atomic Excitation
A graph-model is presented to describe multilevel atomic structure. As an example, we take the double Λ configuration in alkali-metal atoms with hyperfine structure and nuclear spin I = 3 / 2 , as a graph with four vertices.
Abu Mohamed Alhasan
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Biophysical approaches for studying viral entry
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Deep Hashing Similarity Learning for Cross-Modal Retrieval
In the realm of cross-modal retrieval research, hash methods have garnered significant attention from scholars due to their high retrieval efficiency and low storage costs. However, these methods often sacrifice a considerable amount of semantic features
Ying Ma +3 more
doaj +1 more source
Critical Groups of Simplicial Complexes [PDF]
We generalize the theory of critical groups from graphs to simplicial complexes. Specifically, given a simplicial complex, we define a family of abelian groups in terms of combinatorial Laplacian operators, generalizing the construction of the critical ...
Art M. Duval +2 more
doaj +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The frequency and volume of newly-published scientific literature is quickly making manual maintenance of publicly-available databases of primary data unrealistic and costly.
Kyle H. Ambert +4 more
doaj +1 more source
Cycles intersecting edge-cuts of prescribed sizes [PDF]
We prove that every cubic bridgeless graph $G$ contains a $2$-factor which intersects all (minimal) edge-cuts of size $3$ or $4$. This generalizes an earlier result of the authors, namely that such a $2$-factor exists provided that $G$ is planar.
Tomáš Kaiser, Riste Škrekovski
doaj +1 more source

