Results 81 to 90 of about 3,583,809 (318)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Deep Hashing Similarity Learning for Cross-Modal Retrieval

IEEE Access
In the realm of cross-modal retrieval research, hash methods have garnered significant attention from scholars due to their high retrieval efficiency and low storage costs. However, these methods often sacrifice a considerable amount of semantic features
Ying Ma, Meng Wang, Guangyun Lu, Yajun Sun   +3 more
doaj   +1 more source

Graph Entropy Associated with Multilevel Atomic Excitation

Proceedings, 2020
A graph-model is presented to describe multilevel atomic structure. As an example, we take the double Λ configuration in alkali-metal atoms with hyperfine structure and nuclear spin I = 3 / 2 , as a graph with four vertices.
Abu Mohamed Alhasan
doaj   +1 more source

GraphX: Unifying Data-Parallel and Graph-Parallel Analytics [PDF]

, 2014
From social networks to language modeling, the growing scale and importance of graph data has driven the development of numerous new graph-parallel systems (e.g., Pregel, GraphLab). By restricting the computation that can be expressed and introducing new
Crankshaw, Daniel, Dave, Ankur, Franklin, Michael J., Gonzalez, Joseph E., Stoica, Ion, Xin, Reynold S.   +5 more
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Virk: An Active Learning-based System for Bootstrapping Knowledge Base Development in the Neurosciences

Frontiers in Neuroinformatics, 2013
The frequency and volume of newly-published scientific literature is quickly making manual maintenance of publicly-available databases of primary data unrealistic and costly.
Kyle H. Ambert, Aaron M. Cohen, Gully APC Burns, Eilis eBoudreau, Kemal eSonmez   +4 more
doaj   +1 more source

The graphs cospectral with the pineapple graph

Discrete Applied Mathematics, 2019
The pineapple graph is obtained by appending q pendant edges to a vertex of a complete graph. We prove that among connected graphs, the pineapple graph is determined by its adjacency spectrum. Moreover, we determine all disconnected graphs which are cospectral with a pineapple graph.
Sezer Sorgun, Sezer Sorgun, Willem H. Haemers, Hatice Topcu   +3 more
openaire   +3 more sources

Sampling and Reconstruction of Sparse Signals on Circulant Graphs - An Introduction to Graph-FRI

, 2017
With the objective of employing graphs toward a more generalized theory of signal processing, we present a novel sampling framework for (wavelet-)sparse signals defined on circulant graphs which extends basic properties of Finite Rate of Innovation (FRI)
Dragotti, Pier Luigi, Kotzagiannidis, Madeleine S.   +1 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source