Results 41 to 50 of about 827,001 (270)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
AlgoDeGrafos: An Application to Assist in Course Lectures on Graph Theory
CLEI Electronic Journal, 2009 This paper describes an application of the object-oriented paradigm to the construction of AlgoDeGrafos, a graph-theoretical system enabling the use of graph algorithms.
Denis S. Silveira +2 more
doaj +1 more source
Ordered Tree Decomposition for HRG Rule Extraction [PDF]
Computational Linguistics, 2019 We present algorithms for extracting Hyperedge Replacement Grammar (HRG) rules from a graph along with a vertex order. Our algorithms are based on finding a tree decomposition of smallest width, relative to the vertex order, and then extracting one rule ...
Daniel Gildea +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Clustering graph data: the roadmap to spectral techniques
Discover Artificial IntelligenceGraph data models enable efficient storage, visualization, and analysis of highly interlinked data, by providing the benefits of horizontal scalability and high query performance.
Rahul Mondal +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
GraphTool : a tool for interactive design and manipulation of graphs and graph algorithms [PDF]
, 1990 GraphTool is an interactive tool for editing graphs and visualizing the execution and results of graph algorithms. It runs under both the SunView and X Windows environments and has a full window/mouse interface which is as similar as possible for the two
Bliss, Drew, Dillencourt, Michael B.
core
Unimodal Thompson Sampling for Graph-Structured Arms
, 2016 We study, to the best of our knowledge, the first Bayesian algorithm for unimodal Multi-Armed Bandit (MAB) problems with graph structure. In this setting, each arm corresponds to a node of a graph and each edge provides a relationship, unknown to the ...
Gatti, Nicola +3 more
core +1 more source