Results 41 to 50 of about 832,460 (272)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Outlier edge detection using random graph generation models and applications
Journal of Big Data, 2017 Outliers are samples that are generated by different mechanisms from other normal data samples. Graphs, in particular social network graphs, may contain nodes and edges that are made by scammers, malicious programs or mistakenly by normal users ...
Honglei Zhang +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
AlgoDeGrafos: An Application to Assist in Course Lectures on Graph Theory
CLEI Electronic Journal, 2009 This paper describes an application of the object-oriented paradigm to the construction of AlgoDeGrafos, a graph-theoretical system enabling the use of graph algorithms.
Denis S. Silveira +2 more
doaj +1 more source
Ordered Tree Decomposition for HRG Rule Extraction [PDF]
Computational Linguistics, 2019 We present algorithms for extracting Hyperedge Replacement Grammar (HRG) rules from a graph along with a vertex order. Our algorithms are based on finding a tree decomposition of smallest width, relative to the vertex order, and then extracting one rule ...
Daniel Gildea +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Clustering graph data: the roadmap to spectral techniques
Discover Artificial IntelligenceGraph data models enable efficient storage, visualization, and analysis of highly interlinked data, by providing the benefits of horizontal scalability and high query performance.
Rahul Mondal +5 more
doaj +1 more source
Distributed Triangle Counting in the Graphulo Matrix Math Library
, 2017 Triangle counting is a key algorithm for large graph analysis. The Graphulo library provides a framework for implementing graph algorithms on the Apache Accumulo distributed database.
Hutchison, Dylan
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source