Results 111 to 120 of about 142,988 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Graph properties, graph limits, and entropy [PDF]

, 2017
We study the relation between the growth rate of a graph property and the entropy of the graph limits that arise from graphs with that property. In particular, for hereditary classes we obtain a new description of the coloring number, which by well-known
Janson, Svante,, Balázs Szegedy, Hamed Hatami, Szegedy, Balázs, Hatami, Hamed,, Szegedy, Balazs,, Hatami, H., Janson, Svante, Svante Janson   +8 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Most switching classes with primitive automorphism groups contain graphs with trivial groups

, 2015
The operation of switching a graph Gamma with respect to a subset X of the vertex set interchanges edges and non-edges between X and its complement, leaving the rest of the graph unchanged.
Cameron, Peter Jephson, Spiga, Pablo
core  

Enumeration of connected graph coverings

, 2019
The number of the isomorphism classes of n-fold coverings of a graph G is enumerated by the authors (Canad. J. Math. XLII (1990), 747-761) and Hofmeister (Discrete Math. 98 (1991), 275-183).
Kwak, JH, Lee, J
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A note on intersection dimensions of graph classes [PDF]

, 1995
summary:The intersection dimension of a graph $G$ with respect to a class $\Cal A$ of graphs is the minimum $k$ such that $G$ is the intersection of some $k$ graphs on the vertex set $V(G)$ belonging to $\Cal A$.
Petr Hlineny, Ales Kubena, Kuběna, Aleš, Hliněný, Petr   +3 more
core  

ON A CLASS OF GOLDEN GRAPHS

Advances and Applications in Discrete Mathematics, 2021
Swamy, Narayan, Shinde, Sumedha S., Gudimani, Shaila B., Ramane, H. S.   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exploiting structure to cope with NP-hard graph problems: Polynomial and exponential time exact algorithms [PDF]

, 2010
An ideal algorithm for solving a particular problem always finds an optimal solution, finds such a solution for every possible instance, and finds it in polynomial time.
VAN-'T-HOF, PIM
core