Results 41 to 50 of about 1,256,700 (250)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
OClustR: A new graph-based algorithm for overlapping clustering [PDF]
, 2013 Clustering is a Data Mining technique, which has been widely used in many practical applications. From these applications, there are some, like social network analysis, topic detection and tracking, information retrieval, categorization of digital ...
José Eladio Medina Pagola +3 more
core
A parameter-free graph reduction for spectral clustering and SpectralNet
Array, 2022 Graph-based clustering methods like spectral clustering and SpectralNet are very efficient in detecting clusters of non-convex shapes. Unlike the popular k-means, graph-based clustering methods do not assume that each cluster has a single mean.
Mashaan Alshammari +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Clustering graph data: the roadmap to spectral techniques
Discover Artificial IntelligenceGraph data models enable efficient storage, visualization, and analysis of highly interlinked data, by providing the benefits of horizontal scalability and high query performance.
Rahul Mondal +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
MACOC: a medoid-based ACO clustering algorithm [PDF]
, 2014 The application of ACO-based algorithms in data mining is growing over the last few years and several supervised and unsupervised learning algorithms have been developed using this bio-inspired approach. Most recent works concerning unsupervised learning
Otero, Fernando E. B. +7 more
core +1 more source
FDC-LGL: Fast Discrete Clustering with Local Graph Learning for Large-Scale Datasets
MathematicsGraph-based clustering is a fundamental task in unsupervised machine learning and has been extensively applied to complex data mining scenarios, such as pattern recognition and data classification. However, most existing graph clustering algorithms still
Shenfei Pei, Ruiyu Huang, Zengwei Zheng
doaj +1 more source
A Short Text Clustering Algorithm Based on Spectral Cut [PDF]
Jisuanji gongcheng, 2016 Short text has the characteristics of sparsity and high dimension,and the existing clustering algorithm for the large-scale short text has low accuracy and efficiency.Aiming at this problem,a novel clustering method based on spectral clustering theory ...
LI Xiaohong,XIE Meng,MA Huifang,HE Tingnian
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source