Results 81 to 90 of about 156,516 (263)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A Unified Graph Theory Approach: Clustering and Learning in Criminal Data
MathematicsCrime report clustering plays a critical role in modern law enforcement, enabling the identification of patterns and trends essential for proactive policing.
Haifa Al-Ibrahim, Heba Kurdi
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Bayesian Methods for Graph Clustering [PDF]
, 2009 Networks are used in many scientific fields such as biology, social science, and information technology. They aim at modelling, with edges, the way objects of interest, represented by vertices, are related to each other. Looking for clusters of vertices, also called communities or modules, has appeared to be a powerful approach for capturing the ...
Latouche, Pierre +2 more
openaire +3 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Clustering and domination in perfect graphs
Discrete Applied Mathematics, 1984 A K-Cluster in a graph is an induced sub graph on k-vertices, which maximizes the number of edges. Both the K-Cluster problem and the K-dominating set problem are NP-complete for graphs in general. In this paper we investigate the complexity status of these problems on various subclasses of perfect graphs. In particular, we examine comparability graphs,
Derek G. Corneil, Yehoshua Perl
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Capped
IEEE Access, 2019 As one of the most popular clustering techniques, graph clustering has attracted many researchers in the field of machine learning and data mining. Generally speaking, graph clustering partitions the data points into different categories according to ...
Mulin Chen +3 more
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
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