Results 161 to 170 of about 30,503 (277)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

stGCL: a versatile cross-modality fusion method based on multi-modal graph contrastive learning for spatial transcriptomics. [PDF]

Genome Biol
Yu N, Zhang D, Zhang W, Liu Z, Qiao X, Wang C, Zhao M, Yue W, Li W, De Marinis Y, Gao R.   +10 more
europepmc   +1 more source

Predicting drug-target binding affinity with cross-scale graph contrastive learning. [PDF]

Brief Bioinform, 2023
Wang J, Xiao Y, Shang X, Peng J.
europepmc   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

DMAGCL: A dual-masked adaptive graph contrastive learning framework for predicting circRNA-drug sensitivity. [PDF]

Front Genet
Wang P, Guo Y, Li Z, Tang D, Qi M, Zhu Z, Zhang L.   +6 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Heterogeneous graph contrastive learning for integration and alignment of spatial transcriptomics data. [PDF]

Brief Bioinform
Gui Y, Tan Z, Xu Y, Li C.
europepmc   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Inferring Gene Regulatory Networks From Single-Cell RNA Sequencing Data by Dual-Role Graph Contrastive Learning. [PDF]

Adv Sci (Weinh)
Guan Q, Yu J, Pan J, Yuan F, Ji J, Zhao R, Liu ZP, Liu B, Wu LY, Sun D.   +9 more
europepmc   +1 more source

BiMGCL: rumor detection via bi-directional multi-level graph contrastive learning. [PDF]

PeerJ Comput Sci, 2023
Feng W, Li Y, Li B, Jia Z, Chu Z.
europepmc   +1 more source