Results 41 to 50 of about 30,335 (256)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Improving Graph Collaborative Filtering from the Perspective of User–Item Interaction Directly Using Contrastive Learning

Mathematics
Graph contrastive learning has demonstrated significant superiority for collaborative filtering. These methods typically use augmentation technology to generate contrastive views, and then train graph neural networks with contrastive learning as an ...
Jifeng Dong, Yu Zhou, Shufeng Hao, Ding Feng, Haixia Zheng, Zhenhuan Xu   +5 more
doaj   +1 more source

Learning Material-Aware Local Descriptors for 3D Shapes

, 2018
Material understanding is critical for design, geometric modeling, and analysis of functional objects. We enable material-aware 3D shape analysis by employing a projective convolutional neural network architecture to learn material- aware descriptors ...
Averkiou, Melinos, Bala, Kavita, Chaudhuri, Siddhartha, Kalogerakis, Evangelos, Kim, Vladimir G., Kovacs, Balazs, Lin, Hubert, Ranade, Siddhant   +7 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Unsupervised Bilingual POS Tagging with Markov Random Fields [PDF]

, 2011
In this paper, we give a treatment to the problem of bilingual part-of-speech induction with parallel data. We demonstrate that naïve optimization of log-likelihood with joint MRFs suffers from a severe problem of local maxima, and suggest an alternative
Chen, Desai, Cohen, Shay, Dyer, Chris, Smith, Noah A.   +3 more
core   +4 more sources

ComplementMe: Weakly-Supervised Component Suggestions for 3D Modeling

, 2017
Assembly-based tools provide a powerful modeling paradigm for non-expert shape designers. However, choosing a component from a large shape repository and aligning it to a partial assembly can become a daunting task. In this paper we describe novel neural
Chaudhuri, Siddhartha, Guibas, Leonidas, Kim, Vladimir G., Su, Hao, Sung, Minhyuk   +4 more
core   +1 more source

A Concept of a Digital and Traceable Manufacturing Documentation Based on Formalized Process Description Applied on Composite Aircraft Moveable

Advanced Engineering Materials, EarlyView.
The documentation of component manufacture has become an essential part of today's production processes, especially for the analysis and optimization of production or component design with regard to structural performance, economic efficiency, and sustainability.
Björn Denker, Dominik Delisle, Christian Krombholz, Martin Rädel, Frank Dressel   +4 more
wiley   +1 more source

GRE²-MDCL: Graph Representation Embedding Enhanced via Multidimensional Contrastive Learning

IEEE Access
Graph representation learning aims to preserve graph topology when mapping nodes to vector representations, enabling downstream tasks like node classification and community detection.
Quanjun Li, Weixuan Li, Xiya Zheng, Junhua Zhou, Wenming Zhong, Xuhang Chen, Chao Long   +6 more
doaj   +1 more source

CLB-Defense: based on contrastive learning defense for graph neural network against backdoor attack

Tongxin xuebao, 2023
For the problem that the existing backdoor attack defense methods are difficult to deal with irregular and unstructured discrete graph data to alleviate the threat of backdoor attacks, a backdoor attack defense method for GNN based on contrastive ...
Jinyin CHEN, Haiyang XIONG, Haonan MA, Yayu ZHENG   +3 more
doaj   +2 more sources