Results 41 to 50 of about 6,810,610 (247)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

KAMPNet: multi-source medical knowledge augmented medication prediction network with multi-level graph contrastive learning

BMC Medical Informatics and Decision Making, 2023
Backgrounds Predicting medications is a crucial task in intelligent healthcare systems, aiding doctors in making informed decisions based on electronic medical records (EMR). However, medication prediction faces challenges due to complex relations within
Yang An, Haocheng Tang, Bo Jin, Yi Xu, Xiaopeng Wei   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Bayesian Graph Contrastive Learning [PDF]

, 2022
Contrastive learning has become a key component of self-supervised learning approaches for graph-structured data. Despite their success, existing graph contrastive learning methods are incapable of uncertainty quantification for node representations or ...
Armandpour, Mohammadreza, Duffield, Nick, Zhou, Mingyuan, Narayanan, Krishna, Hajiramezanali, Ehsan, Hasanzadeh, Arman   +5 more
core   +1 more source

GCL-UP: Graph Contrastive Learning via Uncertainty-Aware Perturbation for Few-Shot Node Classification

IEEE Access
Few-shot node classification is a fundamental challenge for Graph Neural Networks (GNNs), where models must generalize from a limited number of labeled nodes.
Hyungjoon Lee, Juntae Kim
doaj   +1 more source

Contrastive Graph Learning for Social Recommendation

Frontiers in Physics, 2022
Owing to the strength in learning representation of the high-order connectivity of graph neural networks (GNN), GNN-based collaborative filtering has been widely adopted in recommender systems.
Yongshuai Zhang, Yongshuai Zhang, Jiajin Huang, Jiajin Huang, Jiajin Huang, Jiajin Huang, Mi Li, Mi Li, Mi Li, Mi Li, Jian Yang, Jian Yang, Jian Yang, Jian Yang   +13 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

GRE²-MDCL: Graph Representation Embedding Enhanced via Multidimensional Contrastive Learning

IEEE Access
Graph representation learning aims to preserve graph topology when mapping nodes to vector representations, enabling downstream tasks like node classification and community detection.
Quanjun Li, Weixuan Li, Xiya Zheng, Junhua Zhou, Wenming Zhong, Xuhang Chen, Chao Long   +6 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source