Results 211 to 220 of about 833,220 (275)

Quantum-augmented graph differential geometry enhances accuracy in protein-protein interaction prediction. [PDF]

Sci Rep
Karthick V, Alshammari FS, Jayasimman IP, Besi PR, Akgul A.   +4 more
europepmc   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

AI-powered TargetMap: Enabling system-level target discovery through full-path reasoning on a unified knowledge graph. [PDF]

iScience
Jin X, Wang S, Chen J, Shen S, Yan F, Wu J, He Q, Xu H, Wu R, Cao J, Yang B.   +10 more
europepmc   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Mechanism of N6-methyladenosine (m6A)-mediated upregulation of LINC00958 in the growth of cervical cancer. [PDF]

Front Oncol
Li Y, Liu Z, Jin H.
europepmc   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Characterizing the Evolution of Inter-Actor Networks in the South China Sea Arbitration via Entropy-Driven Graph Representation Learning from Massive Media Event Data. [PDF]

Entropy (Basel)
Ma M, Yu H, Fang P.
europepmc   +1 more source

Frags2Drugs: A Novel In Silico Fragment-Based Approach to the Discovery of Kinase Inhibitors. [PDF]

Pharmaceuticals (Basel)
Peyrat G, Bournez C, Krezel P, Gally JM, Bourg S, Aci-Sèche S, Bonnet P.   +6 more
europepmc   +1 more source

MoGraphDRP: Multi-omics and graph fusion with bilinear attention for predicting drug sensitivity. [PDF]

PLoS One
Ahmadi Z, Pirgazi J, Sorkhi AG.
europepmc   +1 more source

PepLM-GNN: A graph neural network framework leveraging pre-trained language models for peptide-protein binding prediction. [PDF]

PLoS Comput Biol
Yan K, Li M, Chen S, Liu T, Hao J, Liu B, Li Z.   +6 more
europepmc   +1 more source