Results 301 to 310 of about 3,684,752 (344)

SpatPPI: a geometric deep learning model for predicting protein-protein interactions involving intrinsically disordered regions. [PDF]

Genome Biol
Xu Z, Zhu Y, Han J, Liu J.
europepmc   +1 more source

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

KEGNI: knowledge graph enhanced framework for gene regulatory network inference. [PDF]

Genome Biol
Li P, Li L, Nan J, Chen J, Sun J, Cao Y.
europepmc   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

Quantum graph embedding of transcription factor-gene networks reveals key modules in periodontal bone inflammation: Comparative analysis of GAE and GAN. [PDF]

J Oral Biol Craniofac Res
Yadalam PK.
europepmc   +1 more source

Oatk: a de novo assembly tool for complex plant organelle genomes. [PDF]

Genome Biol
Zhou C, Brown M, Blaxter M, Darwin Tree of Life Project Consortium, McCarthy SA, Durbin R.   +5 more
europepmc   +1 more source

Resolving data bias improves generalization in binding affinity prediction. [PDF]

Nat Mach Intell
Graber D, Stockinger P, Meyer F, Mishra S, Horn C, Buller R.   +5 more
europepmc   +1 more source

A Chinese question and answer system for liver cancer based on knowledge graph and large language mode. [PDF]

Front Artif Intell
Wu H, Zhang M, Wang H, Jiang X, Gao Y, Huang R, Fang Z, Hu X, Fan Y.   +8 more
europepmc   +1 more source

Multi-Modal Topology-Aware Graph Neural Network for Robust Chemical-Protein Interaction Prediction. [PDF]

Int J Mol Sci
Wang J.
europepmc   +1 more source