Results 221 to 230 of about 2,151,737 (304)

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Household water, sanitation, and hygiene practices in Ghana from 1993-2022: a non-linear multivariate Poisson decomposition and traditional predictive modelling approach. [PDF]

Front Public Health
Owusu BA, Salifu Y, Swithin SM, Lasong J, Alhassan A, Salifu T.   +5 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Learning Continuous Decomposable Models Using Mutual Information and Statistical Copulas. [PDF]

Entropy (Basel)
Desuó Neto L, de Oliveira Caetano H, de Souza Sant'Anna Fogliatto M, Dias Maciel C.   +3 more
europepmc   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Spatially structured inflammatory response in the presence of a uniform stimulus. [PDF]

Proc Natl Acad Sci U S A
Jerison ER, Romeo N, Quake SR.
europepmc   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

TCM-DiffRAG: personalized syndrome differentiation reasoning method for traditional Chinese medicine based on knowledge graph and chain of thought. [PDF]

Front Med (Lausanne)
Li J, Chang Y, Liu Y, Wang Y, Ou B, Lin S, Tang SK, Zheng L.   +7 more
europepmc   +1 more source

One‐Pot Direct Recycling of Spent LiCoO2 via Synergistic Binder Defluorination and Phase Reconstruction

Advanced Science, EarlyView.
A Li+‐DES system enables targeted defluorination and synergistic repair of spent LiCoO2 cathodes in a single medium. The regenerated material recovers a well‐ordered layered structure with a high capacity of 157.4 mAh g−1 and 83.1% capacity retention after 300 cycles, demonstrating a sustainable and efficient closed‐loop recycling strategy for lithium ...
Yingjie Hu, Songhu Ye, Fan Li, Chunhui Zhong, Bailin Xiang, Yulan Chen, Lili Zhi, Qingxia Liu, Junfeng Li, Zhixiang Chen   +9 more
wiley   +1 more source

Anti-inflammatory effects of 3PO in asthmatic airway inflammation: an integrated study using network pharmacology, molecular modelling, and <i>in vivo</i> experiments. [PDF]

Front Pharmacol
Huang S, Wei S, Luo F, Cheng Y.
europepmc   +1 more source