Results 41 to 50 of about 46,387 (243)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Graph Coloring Using Eigenvalue Decomposition [PDF]

open access: yesSIAM Journal on Algebraic Discrete Methods, 1984
A heuristic algorithm for proper vertex colouring of a graph which is based on eigenvectors of the adjacency matrix is proposed in this paper. Signs of coordinates of the eigenvector belonging to the least eigenvalue determine a 2-colouring. This colouring is refined using gradually other eigenvectors in a similar way.
Aspvall, Bengt, Gilbert, John R.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Notes on upper bounds for the largest eigenvalue based on edge-decompositions of a signed graph

open access: yesKuwait Journal of Science, 2023
The adjacency matrix of a signed graph has +1 or -1 for adjacent vertices, depending on the sign of the connecting edge. According to this concept, an ordinary graph can be interpreted as a signed graph without negative edges.
Zoran Stanić
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Structural Decomposition of Reactions of Graph-Like Objects [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2010
Inspired by decomposition problems in rule-based formalisms in Computational Systems Biology and recent work on compositionality in graph transformation, this paper proposes to use arbitrary colimits to "deconstruct" models of reactions in which states ...
Tobias Heindel
doaj   +1 more source

On the decomposition of circulant graphs using algorithmic approaches

open access: yesAlexandria Engineering Journal, 2022
Many structural models in chemistry, biology, computer science, sociology, and operations research can be analyzed using graph theory. Some examples of these structure models are species movement between regions, molecular bonds, shortest spanning trees,
A. El-Mesady, Y.S. Hamed, H. Shabana
doaj   +1 more source

Highly irregular graph decompositions

open access: yesTheoretical Computer Science
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bensmail, Julien   +3 more
openaire   +2 more sources

Engineered Mycelial Scaffolds With Tunable Ultraviolet Protection, Wettability, Thermal Stability, and Spatial Mechanics

open access: yesAdvanced Engineering Materials, EarlyView.
Fungal mycelia grown into biodegradable scaffolds and infused with titania nanoparticles show enhanced ultraviolet shielding, thermal protection, and surface nonwettability. Properties were tuned by drying methods, revealing structure–function relationships.
Juwon S. Afolayan   +2 more
wiley   +1 more source

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