Results 221 to 230 of about 802,028 (300)

Hierarchically Rough rGO/HAp Nanocoatings on SLM Ti–6Al–4 V Implants for Enhanced Biointegration

open access: yesSmall, EarlyView.
This study investigates HAp/rGO bioactive coatings on Ti‐6Al‐4V fixation implants fabricated by selective laser melting with systematically varied volumetric energy density to tailor the as‐built surface state. Composite coatings were deposited by electrophoretic deposition and characterized using micro‐CT, profilometry, FESEM/EDS, and detailed XPS to ...
Muhammad Usama Zaheer   +9 more
wiley   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

open access: yesSmall, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron   +11 more
wiley   +1 more source

Engineering Flexible Nanofibrous Hydroxyapatite Scaffolds With Tunable Degradation and Mechanical Properties for Bone Regeneration

open access: yesSmall, EarlyView.
Conventional hydroxyapatite ceramics are brittle and poorly resorbable, limiting their use in bone repair. To overcome these limitations, flexible scaffolds are fabricated using ceramic nanofibers as structural building blocks. Adjusting nanofiber characteristics allows modulating the mechanical properties and degradation, providing a versatile ...
Raúl Agut López   +4 more
wiley   +1 more source

3D chemotaxis chip for investigating natural killer cell migration mechanisms. [PDF]

open access: yesFront Immunol
Temples MN   +5 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

Influence of Surface Roughness and Temperature on Niobium Cathodic Cage Duplex Treatment Applied to VP20TS Steel

open access: yessteel research international, EarlyView.
Niobium cathodic cage duplex treatment is applied to VP20TS steel to evaluate the influence of surface roughness and temperature on coating performance. Results show that higher temperatures promote thicker nitride layers and increased microhardness, while finer surface preparation enhances adhesion and wear resistance, revealing optimal conditions for
Alan Bruno Costa Cardoso   +6 more
wiley   +1 more source

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