Results 121 to 130 of about 2,693,458 (344)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Labeling angles of planar graphs
Discrete Mathematics, 1988 By a well-known theorem of Heawood, 3-edge-coloring bridgeless planar cubic graphs is equivalent to labeling vertices with \(+1\) or -1 so that the sum around any face is 0(mod 3). The authors introduce the notion of ``angle-labeling'' and prove results analogous to Heawood's for bridgeless planar graphs with vertices of degree 2 or 3; the angles and ...
Feodor Loupekine, John J. Watkins
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
SOME RESULTS OF LABELING ON BROOM GRAPH [PDF]
, 2015 A Broom Graph Bn,d is a graph of n vertices, which have a path P with d vertices and (n-d) pendant vertices, all of these being adjacent to either the origin u or the terminus v of the path P.
core +1 more source
Measuring the Similarity of Labeled Graphs [PDF]
, 2007 This paper proposes a similarity measure to compare cases represented by labeled graphs. We first define an expressive model of directed labeled graph, allowing multiple labels on vertices and edges. Then we define the similarity problem as the search of a best mapping, where a mapping is a correspondence between vertices of the graphs.
Pierre-Antoine Champin, Christine Solnon
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 1997 This document describes a scheme for labeling a program dependence graph (PDG) or control flow graph (CFG) in order to codify the hierarchical control dependence structure of a procedure. The first section describes the scheme and its features. Section 2
Chris J. Newburn, Node Labeling
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Graph Pattern Matching: From Intractable to Polynomial Time [PDF]
, 2010 Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong +5 more
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