Results 111 to 120 of about 7,663 (277)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Distance-two labelings of digraphs

, 2004
For positive integers $j\ge k$, an $L(j,k)$-labeling of a digraph $D$ is a function $f$ from $V(D)$ into the set of nonnegative integers such that $|f(x)-f(y)|\ge j$ if $x$ is adjacent to $y$ in $D$ and $|f(x)-f(y)|\ge k$ if $x$ is of distant two to $y ...
Chang, G. J., Chen, J. -J., Kuo, D., Liaw, S. C.   +3 more
core   +1 more source

Prime Labelings of Snake Graphs

The PUMP Journal of Undergraduate Research, 2019
A prime labeling of a graph G with n vertices is a labeling of the vertices with distinct integers from the set {1, 2 ,..., n} such that the labels of any two adjacent vertices are relatively prime. In this paper, we introduce a snake graph, the fused union of identical cycles, and define a consecutive snake prime labeling for this new family of graphs.
Abigail Bigham, Elizabeth Ann Donovan, James Pack, Jordan Turley, Lesley Wiglesworth   +4 more
openaire   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The sandwich theorem

, 1993
This report contains expository notes about a function $\vartheta(G)$ that is popularly known as the Lov\'asz number of a graph~$G$. There are many ways to define $\vartheta(G)$, and the surprising variety of different characterizations indicates in ...
Knuth, Donald E.
core   +2 more sources

Bounds of Strong EMT Strength for certain Subdivision of Star and Bistar

Open Mathematics, 2018
A super edge-magic total (SEMT) labeling of a graph ℘(V, E) is a one-one map ϒ from V(℘)∪E(℘) onto {1, 2,…,|V (℘)∪E(℘) |} such that ∃ a constant “a” satisfying ϒ(υ) + ϒ(υν) + ϒ(ν) = a, for each edge υν ∈E(℘), moreover all vertices must receive the ...
Kanwal Salma, Riasat Ayesha, Imtiaz Mariam, Iftikhar Zurdat, Javed Sana, Ashraf Rehana   +5 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

On Super Edge-Antimagic Total Labeling Of Subdivided Stars

Discussiones Mathematicae Graph Theory, 2014
In 1980, Enomoto et al. proposed the conjecture that every tree is a super (a, 0)-edge-antimagic total graph. In this paper, we give a partial sup- port for the correctness of this conjecture by formulating some super (a, d)- edge-antimagic total ...
Javaid Muhammad
doaj   +1 more source

Decomposition of complete graphs into connected unicyclic graphs with eight edges and pentagon

Indonesian Journal of Combinatorics, 2019
A G-decomposition of the complete graph Kn is a family of pairwise edge disjoint subgraphs of Kn, all isomorphic to G, such that every edge of Kn belongs to exactly one copy of G.
Dalibor Froncek, O'Neill Kingston
doaj   +1 more source