Results 71 to 80 of about 91,504 (262)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ENDNet: Extra-Node Decision Network for Subgraph Matching

IEEE Access
Subgraph matching, which involves identifying a query graph within a larger data graph, is a fundamental problem that has applications in various fields.
Masaki Shirotani, Motoki Amagasaki, Masato Kiyama   +2 more
doaj   +1 more source

Polynomial reconstruction of the matching polynomial

Electronic Journal of Graph Theory and Applications, 2015
The matching polynomial of a graph is the generating function of the numbers of its matchings with respect to their cardinality. A graph polynomial is polynomial reconstructible, if its value for a graph can be determined from its values for the vertex ...
Xueliang Li, Yongtang Shi, Martin Trinks
doaj   +1 more source

Matchings in graphs II

Discrete Mathematics, 1975
AbstractProofs are given of theorems of Lovász and Brualdi on the existence in a finite simple graph of matchings required to meet vertices in a given set A of vertices. An alternating chain condition is obtained for a maximum matching to meet all the vertices in A.
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Modification and completion of geological structure knowledge graph based on pattern matching

Scientific Reports
As a knowledge representation method, knowledge graph is widely used in intelligent question answering systems and recommendation systems. At present, the research on knowledge graph mainly focuses on information query and retrieval based on knowledge ...
Cai Lu, Xinran Xu, Bingbin Zhang
doaj   +1 more source

Advanced weight graph transformation matching algorithm

IET Computer Vision, 2015
An efficient and accurate point matching algorithm named advanced weight graph transformation matching (AWGTM) is proposed in this study. Instead of relying only on the elimination of dubious matches, the method iteratively reserve correspondences which ...
Song Wang, Xin Guo, Xiaomin Mu, Yahong Huo, Lin Qi   +4 more
doaj   +1 more source

Generalized Matching Preclusion in Bipartite Graphs

Theory and Applications of Graphs, 2018
The matching preclusion number of a graph with an even number of vertices is the minimum number of edges whose deletion results in a graph that has no perfect matchings. For many interconnection networks, the optimal such sets are precisely sets of edges
Zachary Wheeler, Eddie Cheng, Dana Ferranti, Laszlo Liptak, Karthik Nataraj   +4 more
doaj   +1 more source