Results 41 to 50 of about 190,756 (265)
Search for deep graph neural networks
Information Sciences, 2023 Current GNN-oriented NAS methods focus on the search for different layer aggregate components with shallow and simple architectures, which are limited by the 'over-smooth' problem. To further explore the benefits from structural diversity and depth of GNN architectures, we propose a GNN generation pipeline with a novel two-stage search space, which ...
Guosheng Feng +2 more
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Connected graph searching in chordal graphs
Discrete Applied Mathematics, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Comprehensive Review of Path-Planning Algorithms for Planetary Rover Exploration
Remote SensingPath-planning algorithms for planetary rovers are critical for autonomous robotic exploration, enabling the efficient and safe traversal of complex and dynamic extraterrestrial terrains.
Qingliang Miao, Guangfei Wei
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Fast Top-K Graph Similarity Search Via Representative Matrices
IEEE Access, 2018 Graph similarity search is a crucial problem in many applications, such as cheminformatics, data mining, and pattern recognition. Top-k graph similarity search aims to find the most similar k graphs to a query graph in graph databases.
Zhigang Sun, Hongwei Huo, Xiaoyang Chen
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
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Similar Supergraph Search Based on Graph Edit Distance
Algorithms, 2021 Subgraph and supergraph search methods are promising techniques for the development of new drugs. For example, the chemical structure of favipiravir—an antiviral treatment for influenza—resembles the structure of some components of RNA.
Masataka Yamada, Akihiro Inokuchi
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Graph Neural Networks for Graph Search [PDF]
Proceedings of the 3rd Joint International Workshop on Graph Data Management Experiences & Systems (GRADES) and Network Data Analytics (NDA), 2020 Graph neural networks (GNNs) have received more and more attention in past several years, due to the wide applications of graphs and networks, and the superiority of their performance compared to traditional heuristics-driven approaches. However, most existing GNNs still focus on node-level applications, such as node classification and link prediction,
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source