Results 51 to 60 of about 358,315 (287)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph
Engineering, 2018 The biggest bottleneck in DNA computing is exponential explosion, in which the DNA molecules used as data in information processing grow exponentially with an increase of problem size.
Jin Xu +4 more
doaj +1 more source
Breaking Symmetries in Graph Representation [PDF]
, 2013 There are many complex combinatorial problems which involve searching for an undirected graph satisfying a certain property. These problems are often highly challenging because of the large number of isomorphic representations of a possible solution.
Codish, M. +3 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
In a World That Counts: Clustering and Detecting Fake Social Engagement at Scale
, 2016 How can web services that depend on user generated content discern fake social engagement activities by spammers from legitimate ones? In this paper, we focus on the social site of YouTube and the problem of identifying bad actors posting inorganic ...
Chen, Xing +4 more
core +1 more source
Efficient Algorithms for Node Disjoint Subgraph Homeomorphism Determination [PDF]
, 2007 Recently, great efforts have been dedicated to researches on the management of large scale graph based data such as WWW, social networks, biological networks.
He, Zhengying +3 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A Novel Global Prototype-Based Node Embedding Technique
IEEE Access, 2022 Node embedding refers to learning or generating low-dimensional representations for nodes in a given graph. In the era of big data and large graphs, there has been a growing interest in node embedding across a wide range of applications, ranging from ...
Zyad Alkayem +4 more
doaj +1 more source
Contraction Obstructions for Connected Graph Searching [PDF]
, 2015 We consider the connected variant of the classic mixed search game where, in each search step, cleaned edges form a connected subgraph. We consider graph classes with bounded connected (and monotone) mixed search number and we deal with the question ...
Best, Micah J. +3 more
core
Searching for rewards in graph-structured spaces
, 2019 How do people generalize and explore structured spaces? We study human behavior on a multi-armed bandit task, where rewards are influenced by the connectivity structure of a graph.
Gershman, S., Schulz, E., Wu, C.
core +1 more source