Results 61 to 70 of about 358,315 (287)

Graph Neural Networks for Graph Search [PDF]

Proceedings of the 3rd Joint International Workshop on Graph Data Management Experiences & Systems (GRADES) and Network Data Analytics (NDA), 2020
Graph neural networks (GNNs) have received more and more attention in past several years, due to the wide applications of graphs and networks, and the superiority of their performance compared to traditional heuristics-driven approaches. However, most existing GNNs still focus on node-level applications, such as node classification and link prediction,
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Multiplex graph matching matched filters

Applied Network Science, 2022
We consider the problem of detecting a noisy induced multiplex template network in a larger multiplex background network. Our approach, which extends the graph matching matched filter framework of Sussman et al. (IEEE Trans Pattern Anal Mach Intell 42(11)
Konstantinos Pantazis, Daniel L. Sussman, Youngser Park, Zhirui Li, Carey E. Priebe, Vince Lyzinski   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

MEMBANGUN POHON MERENTANG MINIMUM DENGAN MENGGUNAKAN ALGORITMA PRIM [PDF]

, 2009
Graph is the method of discrete problem solution searching that was in the real world. Graph has much of concepts. The ones is Tree concept. Tree concept is being the significant and the popular concept because support to applies graph for a lot of ...
SUSIANI, ERNA
core  

Leveraging graph dimensions in online graph search [PDF]

Proceedings of the VLDB Endowment, 2014
Graphs have been widely used due to its expressive power to model complicated relationships. However, given a graph database D g = { g 1 , g 2 , · · ·, g n
Yuanyuan Zhu, Jeffrey Xu Yu, Lu Qin
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Clustering of tag-induced sub-graphs in complex networks

, 2012
We study the behavior of the clustering coefficient in tagged networks. The rich variety of tags associated with the nodes in the studied systems provide additional information about the entities represented by the nodes which can be important for ...
Aittokallio, Albert, Barabási, Barrat, Benczik, Capocci, Capocci, Castellano, Cattuto, Cattuto, Eguíluz, Ehrhardt, Erdős, Faloutsos, Finocchiaro, Fortunato, Gergely Palla, Ghosal, Gil, Girvan, Holme, Jonsson, Jonsson, Kossinets, Kozma, Lambiotte, Mason, Mendes, Mewes, Newman, Newman, Palla, Palla, Péter Pollner, Ravasz, Resnik, Tamás Vicsek, Vazquez, Vazquez, Watts, Zhu, Zimmermann, Zlatić, Zlatić   +43 more
core   +1 more source