Results 121 to 130 of about 4,335,273 (293)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Discover ComputingSensor networks let a farmer keep their eye on multiple locations in an agricultural field simultaneously but can be expensive to install, maintain and analyse.
Jurgen van den Hoogen +2 more
doaj +1 more source
Signal Processing on Directed Graphs
, 2020 This paper provides an overview of the current landscape of signal processing (SP) on directed graphs (digraphs). Directionality is inherent to many real-world (information, transportation, biological) networks and it should play an integral role in processing and learning from network data.
Marques, Antonio G. +2 more
openaire +2 more sources
Graph Signal Reconstruction via Koopman Autoencoder
Real-world graph signals are inherently time-varying and evolve smoothly, making the characterization of such data challenging. We propose a novel approach for reconstructing missing time-varying graph data by leveraging the assumption that the latent ...
Krishnan, S., Park, J., Choi, J.
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Learning Laplacian Matrix in Smooth Graph Signal Representations
The construction of a meaningful graph plays a crucial role in the success of many graph-based representations and algorithms for handling structured data, especially in the emerging field of graph signal processing.
Dong, Xiaowen +3 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Graph-Based EEG Signal Compression for Human–Machine Interaction
IEEE AccessCommunication of bioelectric signals, such as electroencephalography (EEG) signals, will be a key technology for smooth interaction between users and remote robots.
Takuya Fujihashi, Toshiaki Koike-Akino
doaj +1 more source