Results 41 to 50 of about 636 (117)

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Microanatomical features of bovids long bones: What are the effects of mass and habitat?

Journal of Anatomy, EarlyView.
This study provides the first qualitative and quantitative exploration of inter‐bones and interspecific variations in the microanatomy of long bones in bovids in response to significant changes in body mass and habitat. Abstract Bovids are a valuable group for studying limb long bone adaptations due to differences in size and the environment that the ...
Morgan Proust, Cyril Etienne, Alexandra Houssaye   +2 more
wiley   +1 more source

Network‐level disconnectivity tracks poststroke depressive symptom improvement

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Poststroke depression is the most common psychological condition following a stroke and can severely impact outcome. However, the neurobiological biomarkers associated with recovery of poststroke depression remain unclear. In this longitudinal observational study, we set out to investigate the effect of lesion‐induced focal damage and network ...
Aleksi J. Sihvonen, Sonia L. E. Brownsett, David A. Copland, Alistair Walsh, Stephen M. Davis, Geoffrey A. Donnan, Leeanne M. Carey   +6 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Reversal of economic integration: evidence from European Union enlargement

The Scandinavian Journal of Economics, EarlyView.
Abstract Empirical models of trade agreements implicitly assume that withdrawal from a trade agreement has an equal and opposite trade effect as accession (i.e., symmetry). With increasing opposition to international economic cooperation, it becomes urgent to test this assumption.
Hinnerk Gnutzmann, Arevik Gnutzmann‐Mkrtchyan, Tobias Korn   +2 more
wiley   +1 more source

Does digital surveillance boost citizen compliance? Evidence from China

Political Psychology, Volume 47, Issue 4, August 2026.
Abstract Authoritarian regimes increasingly deploy digital surveillance to monitor citizens, but how this affects citizen compliance remains understudied. We argue that, beyond repressing or deterring regime opponents, digital surveillance serves as an instrument of everyday governance that operates through psychological mechanisms rather than direct ...
Dakeng Chen, Jing Vivian Zhan
wiley   +1 more source

Efficient Self‐Cleaning and Anti‐Bacterial Behavior Realized by Hierarchical Structure in Hybrid Waterborne Polyurethane Coatings Containing Photocatalyst

Advanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
Hybrid WPU coatings with a hierarchical structure are constructed by first directional freezing polymerization of degradable hydrogels with a vertical channel structure and then filling these channels with aqueous WPU solution containing carbon nitride (g‐C3N4) nanosheets.
Xiaobei Zhou, Jing Xu, Jie Yu, Jie Liu, Meiqun Hu, Lie Zhao, Peter Müller‐Buschbaum, Dongming Qi, Qi Zhong   +8 more
wiley   +1 more source

Structural Characterization and Hypoglycemic Effects of a Purified Polysaccharide From Cinnamomum cassia

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
CCP1A, a polysaccharide purified from Cinnamomum cassia with a molecular weight of approximately 8.16 kDa and rich in glucose and galacturonic acid, exerts anti‐type 2 diabetes effects through a multi‐target synergistic mechanism. On one hand, it delays intestinal glucose absorption by inhibiting the activities of α‐amylase and α‐glucosidase in the ...
Liquan Zhou, Yimiao Zhou, Chen Ding, Lin Yang, Tianjin Ma, Xiao Liu, Zuowei Xiao   +6 more
wiley   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, Volume 59, Issue 6, June 2026.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source