Results 51 to 60 of about 333,836 (279)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

A Novel Relevance Feedback Approach Based on Similarity Measure Modification in an X-Ray Image Retrieval System Based on Fuzzy Representation Using Fuzzy Attributed Relational Graph [PDF]

open access: yesJournal of Intelligent Procedures in Electrical Technology, 2011
Relevance feedback approaches is used to improve the performance of content-based image retrieval systems. In this paper, a novel relevance feedback approach based on similarity measure modification in an X-ray image retrieval system based on fuzzy ...
Hossien Pourghassem, Hassan Ghasemian
doaj  

PhAST : pharmacophore alignment search tool [PDF]

open access: yes, 2009
We developed the Pharmacophore Alignment Search Tool (PhAST), a text-based technique for rapid hit and lead structure searching in large compound databases.
Hofmann, Bettina Petra   +4 more
core  

Subgraph Similarity Search in Large Graphs

open access: yes, 2015
One of the major challenges in applications related to social networks, computational biology, collaboration networks etc., is to efficiently search for similar patterns in their underlying graphs. These graphs are typically noisy and contain thousands of vertices and millions of edges.
Samanvi, Kanigalpula, Sivadasan, Naveen
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Privacy-preserving graph similarity search with attribute-based access control

open access: yesCybersecurity
Graph-structured data are integral to applications like social networks, biological systems, cybersecurity, and fraud detection. Outsourcing these data to public clouds offers scalability but raises privacy concerns, as encryption is required before ...
Shawal Khan   +3 more
doaj   +1 more source

Automatic Diagnosis With Efficient Medical Case Searching Based on Evolving Graphs

open access: yesIEEE Access, 2018
The clinical data are often multimodal and consist of both structured data and unstructured data. The modeling of clinical data has become a very important and challenging problem in healthcare big data analytics.
Xiaoli Wang   +4 more
doaj   +1 more source

Personalisasi Modul Similaritas Pencarian Lowongan Kerja dengan Algoritma Extended Weighted Tree Similarity [PDF]

open access: yes, 2013
Extended Weighted Tree Similarity is an algorithm used to get the similarity level between two objects by multiplying and calculating the weight of the objects.
Hendry, H. (Hendry)   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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