Results 31 to 40 of about 123,181 (264)

The Pre-Interictal Network State in Idiopathic Generalized Epilepsies

Brain Sciences, 2023
Generalized spike wave discharges (GSWDs) are the typical electroencephalographic findings of Idiopathic Generalized Epilepsies (IGEs). These discharges are either interictal or ictal and recent evidence suggests differences in their pathogenesis.
Dimitrios Pitetzis, Christos Frantzidis, Elizabeth Psoma, Smaranda Nafsika Ketseridou, Georgia Deretzi, Anna Kalogera-Fountzila, Panagiotis D. Bamidis, Martha Spilioti   +7 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The 'Hub Disruption Index', a reliable index sensitive to the brain networks reorganization. A study of the contralesional hemisphere in stroke

Frontiers in Computational Neuroscience, 2016
Stroke, resulting in focal structural damage, induces changes in brain function at both local and global levels. Following stroke, cerebral networks present structural and functional reorganization to compensate for the dysfunctioning provoked by the ...
Maite Termenon, Maite Termenon, Sophie Achard, Sophie Achard, Assia Jaillard, Assia Jaillard, Assia Jaillard, Chantal Delon-Martin, Chantal Delon-Martin   +8 more
doaj   +1 more source

Prefrontal cortical hemodynamics and functional network organization during Tai Chi standing meditation: an fNIRS study

Frontiers in Human Neuroscience, 2023
IntroductionTai Chi standing meditation (Zhan Zhuang, also called pile standing) is characterized by meditation, deep breathing, and mental focus based on theories of traditional Chinese medicine.
Liping Qi, Guo-Liang Wang, Zhi-Hao Tian, Shuo Guan, Shu-Ye Yang, Yu-Long Yang, Li-Qing Liu, Yong-Zhong Lin   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Adaptation Robotics and Cognitive Load: Use of a Supernumerary Finger for Activities of Daily Living

IEEE Transactions on Neural Systems and Rehabilitation Engineering
This study investigated the impact of Supernumerary Robotic Fingers (SRFs) on cognitive function during activities of daily living (ADLs) among a group of unimpaired individuals.
Rateb Katmah, Mohammad I. Awad, Fatimah Al-Ani, Mohammed Khan, Feryal A. Alskafi, Irfan Hussain, Herbert F. Jelinek, Kinda Khalaf   +7 more
doaj   +1 more source

Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy

Frontiers in Oncology, 2022
IntroductionCognitive impairment has been identified in patients with non-central nervous system cancer received chemotherapy. Chemotherapy-induced changes in the brain are considered as the possible causes of the cognitive deficits of patients.
Yesong Guo, Siwen Liu, Fei Yan, Na Yin, Jie Ni, Chenchen Li, Xuan Pan, Rong Ma, Jianzhong Wu, Shengwei Li, Xiaoyou Li   +10 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Functional whole-brain mechanisms underlying effects of tDCS on athletic performance of male rowing athletes revealed by resting-state fMRI

Frontiers in Psychology, 2022
IntroductionTranscranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that applied to modulate brain activity and enhance motor recovery.
Ming Ma, Yan Xu, Ziliang Xiang, Xi Yang, Jianye Guo, Yong Zhao, Zhenghua Hou, Yuxu Feng, Jianhuai Chen, Yonggui Yuan   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source