Results 101 to 110 of about 2,276,545 (363)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Direct Visual Editing of Node Attributes in Graphs

Informatics, 2016
There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing.
Christian Eichner, Stefan Gladisch, Heidrun Schumann, Christian Tominski   +3 more
doaj   +1 more source

GiViP: A Visual Profiler for Distributed Graph Processing Systems

, 2017
Analyzing large-scale graphs provides valuable insights in different application scenarios. While many graph processing systems working on top of distributed infrastructures have been proposed to deal with big graphs, the tasks of profiling and debugging
A Arleo, A Arleo, A Ching, A Lumsdaine, C Ware, D Archambault, D Holten, E Tufte, F Beck, G Battista Di, H Hochheiser, H Stitz, HC Purchase, HC Purchase, HC Purchase, HR Dehkordi, J Cohen, J Heer, JM Six, L Byron, L Gabrielli, LG Valiant, M Baur, M Behrisch, M Bostock, M Burch, M Krstajic, M Krzywinski, MO Ward, N Elmqvist, N Henry, RR McCune, SL Graham, T Crnovrsanin, U Dogrusoz, W Javed, Y Frishman   +36 more
core   +1 more source

ALOHA: developing an interactive graph-based visualization for dietary supplement knowledge graph through user-centered design

BMC Medical Informatics and Decision Making, 2019
Dietary supplements (DSs) are widely used. However, consumers know little about the safety and efficacy of DSs. There is a growing interest in accessing health information online; however, health information, especially online information on DSs, is ...
Xing He, Rui Zhang, Rubina F. Rizvi, J. Vasilakes, Xi Yang, Yi Guo, Zhennan He, M. Prosperi, J. Huo, J. Alpert, J. Bian   +10 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Shape-Based Quality Metrics for Large Graph Visualization

J. Graph Algorithms Appl., 2015
We propose a new family of quality metrics for graph drawing; in particular, we concentrate on larger graphs. We illustrate these metrics with examples and apply the metrics to data from previous experiments, leading to the suggestion that the new ...
P. Eades, Seok-Hee Hong, A. Nguyen, K. Klein   +3 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Medoid-based shadow value validation and visualization

IJAIN (International Journal of Advances in Intelligent Informatics), 2019
A silhouette index is a well-known measure of an internal criteria validation for the clustering algorithm results. While it is a medoid-based validation index, a centroid-based validation index that is called a centroid-based shadow value (CSV) has been
Weksi Budiaji
doaj   +1 more source

Dynamic Multilevel Graph Visualization

, 2007
We adapt multilevel, force-directed graph layout techniques to visualizing dynamic graphs in which vertices and edges are added and removed in an online fashion (i.e., unpredictably).
Veldhuizen, Todd L.
core   +1 more source

Simultaneous Orthogonal Planarity

, 2016
We introduce and study the $\textit{OrthoSEFE}-k$ problem: Given $k$ planar graphs each with maximum degree 4 and the same vertex set, do they admit an OrthoSEFE, that is, is there an assignment of the vertices to grid points and of the edges to paths on
A Estrella-Balderrama, B Haeupler, BME Moret, BME Moret, CH Papadimitriou, EN Argyriou, G Di Battista, G Di Battista, KR Jampani, KR Jampani, L Auslander, M Jünger, M Schaefer, MA Bekos, P Angelini, P Angelini, P Angelini, Patrizio Angelini, R Tamassia, T Biedl, T Bläsius, T Bläsius, T Bläsius, U Brandes, W Shih   +24 more
core   +1 more source