Results 111 to 120 of about 2,276,545 (363)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Graph Visualization Tools: A Comparative Analysis
JISR on Computing, 2015 Data visualization is becoming a necessity for big organizations as the social networking data is growing rapidly. It is becoming difficult to visualize data and perform complex comparisons.
Fariha Majeed, Saif-ur-Rahman
doaj +1 more source
Statistical Analysis and Parameter Selection for Mapper [PDF]
, 2017 In this article, we study the question of the statistical convergence of the 1-dimensional Mapper to its continuous analogue, the Reeb graph. We show that the Mapper is an optimal estimator of the Reeb graph, which gives, as a byproduct, a method to ...
Carrière, Mathieu +2 more
core +2 more sources
Peacock Bundles: Bundle Coloring for Graphs with Globality-Locality Trade-off
, 2016 Bundling of graph edges (node-to-node connections) is a common technique to enhance visibility of overall trends in the edge structure of a large graph layout, and a large variety of bundling algorithms have been proposed.
A Telea +14 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Recognizing Weighted Disk Contact Graphs
, 2015 Disk contact representations realize graphs by mapping vertices bijectively to interior-disjoint disks in the plane such that two disks touch each other if and only if the corresponding vertices are adjacent in the graph.
Klemz, Boris +2 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Visual Detection of Structural Changes in Time-Varying Graphs Using Persistent Homology
, 2017 Topological data analysis is an emerging area in exploratory data analysis and data mining. Its main tool, persistent homology, has become a popular technique to study the structure of complex, high-dimensional data.
Hajij, Mustafa +3 more
core +1 more source
Proceedings of the 29th International Symposium on Graph Drawing and Network Visualization (GD 2021) [PDF]
, 2021 Helen C. Purchase, Ignaz Rutter
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source