Results 161 to 170 of about 41,536 (269)

Restraint care in the pediatric intensive care unit: a qualitative investigation of nurses' perspectives and experiences. [PDF]

Front Pediatr
Dai X, Liu Q, Ma S, Wei L.
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The Experience of Spanish Cancer Patients and Professionals With Quality of Life Assessment in Clinical Practice. [PDF]

J Patient Exp
Arraras JI, Illarramendi JJ, Manterola A, de la Cruz S, Teijeira L, Salgado E, Lecumberri MJ, Ibañez B, Vera R.   +8 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

How Should We Communicate Information Regarding Birth Choices to Women?: An Online Randomised Survey. [PDF]

BJOG
Bradley V, Hunt A, Bunni E, Kingdon C, Finikarides L, Bonnett L, Cunningham C, Burden C, Ficquet J, Parry-Smith W, Oteroromero E, Rezvani A, Black M, Clayton G, Smith GCS, Lawlor D, Heron J, Merriel A, Options Study Collaborative Group.   +18 more
europepmc   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Best Case/Worst Case Communication Tool for Trauma Intensive Care Units.

JAMA Surg
Fritz ML, Hernandez AH, Zelenski AB, Nitkowski J, Sobol C, Kwekkeboom K, Bradley T, Tsang J, Bushaw K, Dudek A, Stalter L, Schwarze ML.   +11 more
europepmc   +1 more source

Emerging Horizons: The Confluence of Artificial Intelligence and Graphic Medicine in Healthcare Education and Dentistry. [PDF]

Cureus
Dutta D, Raut A, Mohanty AK, Samantaray S, Roy I.   +4 more
europepmc   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Enhancing Neonatal Intensive Care Unit (NICU) Paternal Satisfaction: A Comparative Study of Traditional vs. Generative AI-Integrated Counseling. [PDF]

Cureus
Joshi A, Shubham S, Ahmed SM, Mishra D, Joshi R, Puri N, Gupta G.   +6 more
europepmc   +1 more source