E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Visual Health Analysis of Print Advertising Graphic Design Based on Image Segmentation and Few-Shot Learning. [PDF]
Comput Intell Neurosci, 2022 Hu S.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Using Off-the-Shelf Graphic Design Software for Validating the Operation of an Image Processing System. [PDF]
Sensors (Basel), 2021 Chrząszcz J.
europepmc +1 more source
Event review of 'De-Brief : Interrogating the Graphic Design Brief' at University of Salford, 9th September 2015 [PDF]
, 2015 Event review of ‘De-Brief: Interrogating the Graphic Design Brief’, the inaugural symposium of the Graphic Design Educators’ Network, a new subject association, held at University of Salford on 9th September ...
Wood, Emily
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Graphic Reconstruction of a Roman Mosaic with Animal Emblems and Its Digital Interpretation
HeritageThis contribution examines the use of ICT in mosaic heritage to enhance the user experience in heritage interpretation. The study focuses on the digital graphic reconstruction of a Roman mosaic featuring animal emblems.
Tanja Nuša Kočevar +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
How Graphic Visual Health Warnings Affect Young Smokers\u27 Thoughts of Quitting [PDF]
, 2014 Two-thirds of adolescent and young adult smokers become lifetime smokers, and one-half of those lifetime smokers will die from this habit. The authors examine alternative persuasive pathways to thoughts of quitting taken by adolescent and young adult ...
Andrews, J. Craig +3 more
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source