Results 121 to 130 of about 852,315 (263)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Blogs, Reflective Practice and Autonomous Learning in Graphic Design Communication [PDF]

open access: yes, 2007
Since their inception in 2004 Blogs have become a major contributor to the development of the social networking phenomenon. This paper reports on a small qualitative research project utilising case studies of the use of blogs by Level2 BA Graphic Design ...
Maloney, Peter
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Animation graphic interface for the space shuttle onboard computer [PDF]

open access: yes
Graphics interfaces designed to operate on space qualified hardware challenge software designers to display complex information under processing power and physical size constraints. Under contract to Johnson Space Center, MICROEXPERT Systems is currently
Griffith, Paul, Wike, Jeffrey
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Ilio Negri, metodo e ragione grafica [PDF]

open access: yes, 2015
open1Piccolo contributo monografico dedicato al lavoro del graphic designer Ilio Negri (Milano, 1926-1974), i cui materiali sono conservati nel Fondo Ilio Negri depositato presso il Centro di Documentazione sul Progetto Grafico di Aiap, Associazione ...

core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Graphic Reconstruction of a Roman Mosaic with Animal Emblems and Its Digital Interpretation

open access: yesHeritage
This contribution examines the use of ICT in mosaic heritage to enhance the user experience in heritage interpretation. The study focuses on the digital graphic reconstruction of a Roman mosaic featuring animal emblems.
Tanja Nuša Kočevar   +4 more
doaj   +1 more source

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