Results 71 to 80 of about 9,933,249 (277)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
University Unions Graphic Design Office Student Work 1993
, 2011 Graphic design work produced by UUGDO student designers in 1992-1993http://deepblue.lib.umich.edu/bitstream/2027.42/87945/1/FY1993 ...
University Unions Graphic Design Office, University of Michigan
core +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
University Unions Graphic Design Office Student Work 1990
, 2011 Graphic design work produced by UUGDO student designers in 1989-1990http://deepblue.lib.umich.edu/bitstream/2027.42/87942/1/FY1990 ...
University Unions Graphic Design Office, University of Michigan
core +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Fashion and TextilesRecently, there has been a lot of interest in industry and academia in virtual influencers (VIs). This study aimed to augment the understanding of VI marketing by exploring the relationship between VI’s characteristics (i.e., their humanlikeness level ...
Naan Ju, Terry Kim, Hyunjoo Im
doaj +1 more source
Digital works of Art inspired by Miniatures and Mosaics of Abbasid Artist wasiti
Journal of Architecture, Art & Humanistic Science, 2017 Picture drawing as an art peaked in the late Abbasid era in the context of illustrations accompanying Maqamat Al Hariri stories in Bagdad the seat of the Caliphate, and cultural hub of the civilized world of the Middle Ages.
Aida Jokhosha
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The analysis of ink jet printed eco-font efficiency
Journal of Graphic Engineering and Design, 2016 Utilization of eco-font for office printing is one of sustainable, “green” printing concepts, which besides obvious economic benefits, as a result has a certain effect on environmental sustainability as well.
Rastko Milošević +4 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source