Results 101 to 110 of about 67,416 (348)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Millennial gothic : on Runberg, Homs and Carot’s graphic novel adaptation of Stieg Larsson’s Millennium trilogy

open access: yes, 2017
A modern classic and a true cross-media phenomenon, Stieg Larsson's Millennium trilogy (2005-2007) has been filmed both in Sweden and in the U.S. and adapted into two graphic novel narratives .
STORSKOG, CAMILLA CARITA   +1 more
core   +1 more source

Some Vector Inequalities for Continuous Functions of Self-Adjoint Operators in Hilbert Spaces

open access: yesJournal of Inequalities and Applications, 2011
On utilizing the spectral representation of self-adjoint operators in Hilbert spaces, some inequalities for the composite operator , where and for various classes of continuous functions are given.
Dragomir SS
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

A nation's visual language: nation branding and the visual identity of contemporary Malaysia

open access: yes, 2011
This research explores the role graphic design can play in the national branding of emergent nations, and takes the multiracial, multicultural state of Malaysia as the principal object of study.
Gan, DSS
core  

Analysis of graphic codes for colour representation: ColorADD and Feelipa Color Code in Portuguese companies

open access: yes, 2018
This article is the result of initial tests and studies about two systems for chromatic representation. It introduces and discusses the use and importance of two graphic codes created in Portugal as well as their graphic application on information and ...
Trigueiros, Paula   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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