Results 51 to 60 of about 184,966 (290)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Exploring search behaviour across expertise levels: Graphical vs. form-based interfaces

Information Research: An International Electronic Journal
Introduction. This study explores how graphical and form-based search interfaces influence query reformulation strategies and search performance across two user cohorts: search professionals and master’s students. Method. Using a lab-based user study,
Tony Russell-Rose, Tanja Svarre
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Toward the adaptation of component-based architectures by model transformation: behind smart user interfaces [PDF]

, 1998
Graphical user interfaces are not always developed for remaining static. There are GUIs with the need of implementing some variability mechanisms. Component-based GUIs are an ideal target for incorporating this kind of operations, because they can adapt ...
Daniel, Batty, Galitz WO, Iribarne, Gruber, Mikroyannidis, O'Reilly, Iribarne, Iribarne, Cheng, Salehie, Blair, Crnkovic, Bencomo N, Calvary, Iribarne, Cetina C, Seinturier, Gui, Pantsar-Syvaniemi, Garlan, Grundy, Wimmer, Kruchten, Hnětynka, Steinberg, Kurtev, Wagelaar, Warmer, Jouault, Arora, Morin, Floch, Hallsteinsen, Hinchey, Kolovos, Porres, Bollati, Paulheim   +38 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Designing Search: Effective Search Interfaces for Academic Library Websites [PDF]

, 2008
Academic libraries customize, support and provide access to myriad information systems, each with complex graphical user interfaces (GUIs). The number of possible information entry points on an academic library Web site is both daunting to the end user ...
Ghaphery, Jimmy, Rector, Susan Teague
core   +3 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Graphical User Interfaces for Molecular Dynamics—Quo Vadis?

Bioinformatics and Biology Insights, 2009
In the past years an increasing number of graphical user interfaces for Molecular Dynamics (MD) were presented and concomitantly, more and more Molecular Dynamics studies were published.
B. Knapp, W. Schreiner
doaj  

Solving Multicriteria Optimization Problems with WebOptim Software System

Cybernetics and Information Technologies, 2015
This paper is a presentation of a web based decision support system “WebOptim” for solving single and multiple criteria optimization problems. It targets a wide range of user typeseducators, researchers, managers and business people. It also provides two
Staykov Boris
doaj   +1 more source