Results 41 to 50 of about 174,773 (267)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

“I Am not an Observer, I Am a Participant”. On Josef Čapek’s Pre-War Caricature [PDF]

open access: yesХудожественная культура
The article focuses on a little-studied facet of the vast oeuvre of the artist and writer Josef Čapek (1887–1945), an important figure in the Czech avant-garde of the early 20th century and one of the founders of Czech Expressionism and Cubism. The study
Vinogradova Elena K.
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

«Сибирский стиль» Антонины Емельяновой

open access: yesИскусство Евразии, 2020
В статье рассматривается творческое наследие ученицы Иркутской художественной мастерской-студии И.Л. Копылова Антонины Емельяновой. Она принимала активное участие в культурной жизни Иркутска 1920-х, была отмечена своим учителем, а также художественными ...
Аверьянова, Мария Александровна
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Characters Segmentation of Cursive Handwritten Words based on Contour Analysis and Neural Network Validation

open access: yesJournal of ICT Research and Applications, 2013
This paper presents a robust algorithm to identify the letter boundaries in images of unconstrained handwritten word . The proposed algorithm is based on  vertical  contour  analysis.
Fajri Kurniawan   +4 more
doaj  

Exploring quantum annealing for coarse-grained protein folding

open access: yesScientific Reports
We explore the potential application of quantum annealing to address the protein structure problem. To this end, we compare several proposed ab initio protein folding models for quantum computers and analyze their scaling and performance for classical ...
Timon Scheiber   +2 more
doaj   +1 more source

A graphical calculus

open access: yes, 1995
We present a graphical calculus, which allows mathematical formulae to be represented and reasoned about using a visual representation. We define how a formula may be represented by a graph, and present a number of laws for transforming graphs, and describe the effects these transformations have on the corresponding formulae.
Curtis, S, Lowe, G
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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