Results 21 to 30 of about 5,425 (212)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Oil & Gas Science and Technology, 2006 Shell Research has developed an integrated well-performance simulation tool that is widely used throughout the Shell Group. However, users do not fully appreciate its advanced functionality because of the cumbersome way in which relevant input data have ...
Overboom G. R.
doaj +1 more source
Auditory Representations of a Graphical User Interface for a Better Human-Computer Interaction [PDF]
, 2010 As part of a project to improve human computer interaction mostly for blind users, a survey with 50 blind and 100 sighted users included a questionnaire about their user habits during everyday use of personal computers. Based on their answers, the most important functions and applications were selected and results of the two groups were compared ...
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Communication, Machines & Human Augmentics
communication +1, 2016 This essay reformulates the question of human augmentation as a problem of advanced human-machine communication, theorizing that such communication implies robust artificial intelligence and necessitates understanding the relational role new technologies
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Научно-технический вестник информационных технологий, механики и оптикиThis paper addresses the task of generating animations of a digital avatar that synchronously reproduces speech, facial expressions, and gestures based on a bimodal input — namely, a static image and an emotionally colored text.
A. A. Axyonov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source