Results 31 to 40 of about 252,220 (294)

Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

Nature Communications
Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ).
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim   +34 more
doaj   +1 more source

Electrochemical Behavior of Flame‐Sprayed Sc‐Doped AlCoCrFeMo High‐Entropy Alloy Coatings in 3.5% Sodium Chloride Solution

Advanced Engineering Materials, EarlyView.
Scandium (Sc)‐doped AlCoCrFeMo HEA coatings are fabricated via flame spraying with 0.1, 0.3, and 0.5 wt% Sc additions. Among these, the HEA‐Sc0.3 coating exhibits the highest corrosion resistance, indicated by a more positive corrosion potential and lower current density.
Pankaj Kumar, Akash Vyas, Mohammad Aatif Qazi, Nashit Jalal, Maria Ophelia Jarligo, Mostafa Yakout, Jing Liu, André McDonald   +7 more
wiley   +1 more source

Dynamic Microstructural Evolution of Graphite under Displacing Irradiation [PDF]

, 2014
Graphitic materials and graphite composites experience dimensional change when exposed to radiation-induced atomic displacements. This has major implications for current and future technological ranging from nuclear fission reactors to the processing ...
Haigh, S. J., Greaves, Graeme, Sweeney, Francis, Haigh, S. J.; id_orcid, Donnelly, S. E., Hinks, J. A., Pan, C. T., Greaves, G., Young, R. J.; id_orcid, Sweeney, F., Young, R. J.   +10 more
core   +1 more source

Influence of Scan Strategies in Electron Beam Powder Bed Fusion on Solidification, Microstructure, and High‐Temperature Compressive Properties of γ′‐Strengthened Inconel 738LC

Advanced Engineering Materials, EarlyView.
Experiments and thermophysical simulations were conducted to investigate the electron beam powder bed fusion electron beam (PBF‐EB/M) process for the γ′‐strengthened nickel‐based superalloy Inconel 738LC. The results demonstrate the impact of process‐induced microstructural variations on high‐temperature mechanical behavior, providing a basis for ...
Jan Niklas Petenati, Karthik Kumar Banku, Prasanth Bondi, Ivan Zhirnov, Yangyiwei Yang, Gordon Schmidt, Jürgen Christen, Georg Hasemann, Manja Krüger, Bai‐Xiang Xu, Bilal Gökce, Silja‐Katharina Rittinghaus   +11 more
wiley   +1 more source

Rapidly Solidified High‐Strength Invar 36 Prepared by Planar‐Flow Melt Spinning

Advanced Engineering Materials, EarlyView.
The Invar 36 alloy was rapidly solidified using the planar‐flow melt‐spinning technique. Ribbon samples with thicknesses ranging from 20 to 160 mm were produced. As the grain size of the ribbon decreased to sub‐micron levels, the hardness increased by more than 2 times.
Bekir Akgül, Mehmet Kul
wiley   +1 more source

Influence of Chip Breaker Geometric Shape on the Cutting Performance of Cermet Tools

Eng
Ti(C,N)-based cermet turning inserts with two distinct chip breaker groove structures were employed to investigate the influence of chip breaker geometry on cutting performance.
Shuwen Yu, Zengmin Shi, Chengui Deng-Li, Junwen Gao, Lei Dai   +4 more
doaj   +1 more source

Gallium Microalloying in Bi–Sn Solders: Interfacial Phase Formation, Wettability, and Long‐Term Shear Reliability Under Isothermal Aging

Advanced Engineering Materials, EarlyView.
Gallium microalloying redirects interfacial reactions in low‐temperature Bi–Sn solders from Cu–Sn toward Cu–Ga intermetallic formation. The resulting Cu–Ga layer suppresses intermetallic growth during thermal aging, alters fracture pathways, and improves interfacial stability.
Iva Králová, Markéta Klimtová, Mohd Faizul Mohd Sabri, Yew Hoong Wong, Petr Veselý, Martin Plaček, Karel Dušek   +6 more
wiley   +1 more source

Effect of mould inoculation on formation of chunky graphite in heavy section spheroidal graphite cast iron parts [PDF]

, 2007
The manufacturing process of heavy section ductile iron castings is strongly influenced by the risk of graphite degeneration under slow cooling rates.
Asenjo, Iker, Suarez, Ramon, Larrañaga, Peio, Ferrer, Inaki, Gomez, J. -M., Sertucha, Jon, Lacaze, Jacques   +6 more
core   +1 more source

High‐Entropy Alloy Interlayers Toward Advanced Joining for High‐Performance Structural Applications: Current Progress and Emerging Challenges

Advanced Engineering Materials, EarlyView.
HEA interlayers offer a versatile route for joining high‐performance structural materials. Their compositional and structural design regulates interfacial reactions, suppresses brittle IMCs, and improves metallurgical bonding. Sandwich interlayers further integrate defect healing with precipitation strengthening, enabling improved strength–ductility ...
Lin Yuan, Jiafen Song, Jinglong Li, Jiangtao Xiong, Tao Yang   +4 more
wiley   +1 more source

Anisotropic thermal conductivity and permeability of compacted expanded natural graphite [PDF]

, 2010
The anisotropic thermal conductivities and permeabilities are investigated for discs and plates of compacted expanded natural graphite. The measuring directions of heat conductivity and permeability are both parallel and perpendicular to the pressing ...
Tamainot-Telto, Zacharie, Wang, L. W., Wang, R. Z., Critoph, Robert E., Metcalf, Steven J.   +4 more
core   +1 more source