Results 141 to 150 of about 926,750 (319)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Drawing by ear: interpreting sonified line graphs [PDF]
, 2003 The research presented here describes a pilot study into the interpretation of sonified line graphs containing two data series. The experiment aimed to discover the level of accuracy with which sighted people were able to draw sketches of the graphs ...
Lorna M. Brown +3 more
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Routing in Unidirectional (n,k)-star graphs [PDF]
Journal of Systemics, Cybernetics and Informatics, 2006 The class of (n,k)-star graphs and their unidirectional version were introduced as generalizations of star graphs and unidirectional star graphs respectively.
Eddie Cheng, Serge Kruk
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
An Odd Characterization of the Generalized Odd Graphs
2010 Mathematics Subject Classification: 05E30, 05C50;distance-regular graphs;generalized odd graphs;odd-girth;spectra of graphs;spectral excess theorem;spectral ...
Dam, E.R. van, Haemers, W.H.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Spectral Characterization of the Hamming Graphs
We show that the Hamming graph H(3; q) with diameter three is uniquely determined by its spectrum for q ¸ 36. Moreover, we show that for given integer D ¸ 2, any graph cospectral with the Hamming graph H(D; q) is locally the disjoint union of D copies of
Koolen, J.H., Bang, S., Dam, E.R. van
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